(R)-(+)-HA-966

Key Product Details

Product Description

(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Product Specifications for (R)-(+)-HA-966

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (R)-(+)-HA-966

The following data is based on the product molecular weight 116.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	8.61 mL	43.06 mL	86.12 mL
5 mM	1.72 mL	8.61 mL	17.22 mL
10 mM	0.86 mL	4.31 mL	8.61 mL
50 mM	0.17 mL	0.86 mL	1.72 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Pullan Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-MthD.-aspartate receptor complex. J.Neurochem. 1990 PMID: 1975835
• Pullan Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966). Eur.J.Pharmacol. 1991 PMID: 1834473
• Kemp and Priestley Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-MthD.-aspartate receptor agonist responses in cat cultured cortical neurons. Mol.Pharmacol. 1991 PMID: 1674587

Product Documents for (R)-(+)-HA-966