(R,R)-THC

Key Product Details

Product Description

(R,R)-THC is a non-steroidal, selective estrogen receptor ligand. (R,R)-THC is an agonist at ERα receptor (K_i = 9.0 nM) and antagonist at ERβ receptor (K_i = 3.6 nM).

Product Specifications for (R,R)-THC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (R,R)-THC

The following data is based on the product molecular weight 320.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.60 mL	31.21 mL
5 mM	0.62 mL	3.12 mL	6.24 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 84 publications citing the usage of this product.

• Kraichely Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 2000 PMID: 11014206
• Meyers Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes. J.Med.Chem. 1999 PMID: 10395487
• Sun Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β. Endocrinology 1999 PMID: 9927308

Product Documents for (R,R)-THC