R162

Key Product Details

Product Description

R162 is a glutamate dehydrogenase (GHD1) inhibitor (IC₅₀ = 23 μM). Decreases fumarate and ROS levels, attenuates glutathione peroxidase levels and inhibits cell proliferation in cancer cell lines. Attenuates viability of a range of cancer cell lines.

Product Specifications for R162

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for R162

The following data is based on the product molecular weight 264.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.57 mL	37.84 mL	75.68 mL
2.5 mM	1.51 mL	7.57 mL	15.14 mL
5 mM	0.76 mL	3.78 mL	7.57 mL
25 mM	0.15 mL	0.76 mL	1.51 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jin Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 2015 PMID: 25670081

Product Documents for R162