Chemical Name: 1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
Biological ActivityR162 is a glutamate dehydrogenase (GHD1) inhibitor (IC50 = 23 μM). Decreases fumarate and ROS levels, attenuates glutathione peroxidase levels and inhibits cell proliferation in cancer cell lines. Attenuates viability of a range of cancer cell lines.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.
Jin et al.
Cancer Cell., 2015;27:257
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