R18

Catalog # Availability Size / Price Qty
2144/1
Cat.No. 2144 - R18 | Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro | CAS No. 211364-78-2
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Description: Inhibitor of 14.3.3 proteins
Product Details
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Biological Activity

Antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.

Technical Data

M.Wt:
2309.69
Formula:
C101H157N27O29S3
Sequence:
PHCVPRDLSWLDLEANMCLP
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
211364-78-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display.
    Wang et al.
    Biochemistry, 1999;38:12499
  2. 14.3.3 proteins mediate an essential anti-apoptotic signal.
    Masters and Fu
    J.Biol.Chem., 2001;276:45193
  3. Survival-promoting functions of 14.3.3 proteins.
    Masters et al.
    Biochem.Soc.Transactions, 2002;30:360

Product Datasheets

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