Biological ActivityR18 is an antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display.
Wang et al.
14.3.3 proteins mediate an essential anti-apoptotic signal.
Masters and Fu
Survival-promoting functions of 14.3.3 proteins.
Masters et al.
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