Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd
= 6 μ
M). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.
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Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling.
Winkel et al.