RA 839
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Description: Nrf2 activator; inhibits Nrf2/Keap1 interaction
Chemical Name: (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
Purity: ≥98%
Biological Activity
Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.Technical Data
M.Wt:
452.57
Formula:
C25H28N2O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1832713-02-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
-
Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling.
Winkel et al.
J.Biol.Chem., 2015;290:28446
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