Chemical Name: (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
Biological ActivityRA 839 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling.
Winkel et al.
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