RA 839

Key Product Details

Product Description

RA 839 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (K_d = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.

Product Specifications for RA 839

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RA 839

The following data is based on the product molecular weight 452.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.05 mL	22.10 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
10 mM	0.22 mL	1.10 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Winkel Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 2015 PMID: 26459563

Product Documents for RA 839