Chemical Name: 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
Biological Activityrac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.
Koek et al.
Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors.
Malherbe et al.
Citation for rac BHFF
The citations listed below are publications that use Tocris products. Selected citations for rac BHFF include:
1 Citation: Showing 1 - 1
GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
Authors: Zhang Et al.
Clin Exp Dermatol 2015;5:10468
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