rac BHFF

Key Product Details

Product Description

rac BHFF is a potent and selective GABA_B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.

Product Specifications for rac BHFF

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for rac BHFF

The following data is based on the product molecular weight 330.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.14 mL	30.27 mL
5 mM	0.61 mL	3.03 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Koek Discriminative stimulus effects of the GABA_B receptor-positive modulator rac-BHFF: comparison with GABA_B receptor agonists and drugs of abuse. J.Pharmacol.Exp.Ther. 2013 PMID: 23275067
• Malherbe Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABA_B receptors. Br.J.Pharmacol. 2008 PMID: 18536733

Product Documents for rac BHFF