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RAF 265

Catalog #: 6015 Datasheet / COA / SDS

Discontinued Product

6015 has been discontinued.
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RAF 265 | CAS No. 927880-90-8 | Raf Kinase Inhibitors
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Description: Raf kinase and VEGFR-2 inhibitor
Alternative Names: CHIR 265

Chemical Name: 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

Purity: ≥98%

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Biological Activity

RAF 265 is a Raf kinase and VEGFR-2 inhibitor. Inhibits c-Raf, wild type B-Raf and mutant B-Raf (V600E). Cytotoxic in certain melanoma cells lines. Effects enhanced by protein kinase D3 inhibition, preventing reactivation of MAPK signaling and increasing caspase activity. Orally bioavailable.

Technical Data

M.Wt:
518.41
Formula:
C24H16F6N6O
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
927880-90-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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