RANK/TNFRSF11A Antibody - BSA Free

Novus Biologicals | Catalog # NBP3-29939

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all RANK/TNFRSF11A Primary Antibodies »

Product Specifications

Immunogen

Between 450 and 500

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RANK/TNFRSF11A Antibody - BSA Free

RANK/TNFRSF11A Antibody

Immunoprecipitation:RANK/TNFRSF11A AntibodyNBP3-29939] -

Immunoprecipitation:RANK/TNFRSF11A AntibodyNBP3-29939] -Detection of human RANK by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HEK293T cells. Antibodies: Affinity purified rabbit anti-RANK antibody NBP3-29939 used for IP at 6 µg/mg lysate. RANK was also immunoprecipitated by rabbit anti-RANK., which recognizes an upstream epitope. For blotting immunoprecipitated RANK, was used at 1 µg/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Applications for RANK/TNFRSF11A Antibody - BSA Free

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Tris-citrate/phosphate buffer, pH 7 to 8

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: RANK/TNFRSF11A

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family (1). RANK ligand (RANKL/TRANCE/ OPGL) (mAbs to RANKL is also available from Imgenex, Cat # IMG-133) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6 (3,4). Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways (3). Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2 (4).

Long Name

Receptor Activator of NF-kappa-B

Alternate Names

CD265, ODFR, TNFRSF11A, TRANCE R

Gene Symbol

TNFRSF11A

Additional RANK/TNFRSF11A Products

Product Documents for RANK/TNFRSF11A Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for RANK/TNFRSF11A Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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