Chemical Name: (2E)-2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide
Biological ActivityInhibitor of the regulatory subunit PPP1R15B of protein phosphatase (Kd = 33 nM). Displays >30-fold selectivity for PPP1R15B over PPP1R15A. Inhibits PPP1R15B-mediated dephosphorylation and protein synthesis in vitro. Induces transient reduction in protein synthesis in brains of wild type mice after single dose. Decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in a mouse model of Huntington's disease. Orally bioavailable and brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Target-based discovery of an inhibitor of the regulatory phosphatase PPP1R15B.
Krzyzosiak et al.
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