Raphin 1

Key Product Details

Product Description

Raphin 1 is an inhibitor of the regulatory subunit PPP1R15B of protein phosphatase (K_d = 33 nM). Displays >30-fold selectivity for PPP1R15B over PPP1R15A. Inhibits PPP1R15B-mediated dephosphorylation and protein synthesis in vitro. Induces transient reduction in protein synthesis in brains of wild type mice after single dose. Decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in a mouse model of Huntington's disease. Orally bioavailable and brain penetrant.

Product Specifications for Raphin 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Raphin 1

The following data is based on the product molecular weight 231.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.33 mL	21.64 mL	43.28 mL
5 mM	0.87 mL	4.33 mL	8.66 mL
10 mM	0.43 mL	2.16 mL	4.33 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Krzyzosiak Target-based discovery of an inhibitor of the regulatory phosphatase PPP1R15B. Cell. 2018 PMID: 30057111

Product Documents for Raphin 1