Rasagiline mesylate

Catalog # Availability Size / Price Qty
4308/50
Rasagiline mesylate | CAS No. 161735-79-1 | Monoamine Oxidase (MAO) Inhibitors
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Description: Selective and irreversible MAO-B inhibitor

Chemical Name: (1R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine methanesulfonate

Purity: ≥99%

Product Details
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Biological Activity

Selective irreversible MAO-B inhibitor. Displays antiParkinsonian activity; exhibits neuroprotective and antiapoptotic activity against several neurotoxins in cell culture.

Technical Data

M.Wt:
267.34
Formula:
C12H13N.CH3SO3H
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
161735-79-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The anti-parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human DArgic neuroblastoma SH-SY5Y cells.
    Maruyama et al.
    J.Neural Transm., 2002;109:467
  2. Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, rese. reversal, serotonergic and DArgic behaviours.
    Finberg and Youdim
    Neuropharmacology, 2002;43:1110
  3. Molecular basis of neuroprotective activities of rasag. and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].
    Youdim and Weinstock
    Cell.Mol.Neurobiol., 2002;21:555

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