Rauwolscine hydrochloride

Key Product Details

Product Description

Rauwolscine hydrochloride is a standard α₂-adrenergic antagonist (K_i values are 3.5, 4.6, and 0.6 nM at cloned human α_2A, α_2B, and α_2C-adrenoceptors respectively). Partial agonist at 5-HT_1A receptors.

Diastereomer also avilable.

Product Specifications for Rauwolscine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Rauwolscine hydrochloride

The following data is based on the product molecular weight 390.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

13 12 11 10 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.23 mL	51.16 mL	102.33 mL
1.25 mM	2.05 mL	10.23 mL	20.47 mL
2.5 mM	1.02 mL	5.12 mL	10.23 mL
12.5 mM	0.20 mL	1.02 mL	2.05 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hieble β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 1995 PMID: 7658428
• Uhlen [3H]RS79948-197 binding to human, rat, guinea pig and pig α_2A-, α_2B-, and α_2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 1998 PMID: 9551719
• Arthur Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT_1A receptors. Biochem.Pharmacol. 1993 PMID: 8517875

Product Documents for Rauwolscine hydrochloride