Yohimbine hydrochloride

Tocris Bioscience | Catalog # 1127

Selective α2 antagonist
Tocris Bioscience

Key Product Details

Description

Selective α2 antagonist
View all Adrenergic alpha-2 Receptor Antagonists »

Product Description

Yohimbine hydrochloride is a α2-adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors respectively).

Diastereomer also available.

Product Specifications for Yohimbine hydrochloride

Molecular Weight

390.91

Formula

C21H26N2O3.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride

CAS Number

65-19-0

PubChem ID

6169

InChI Key

PIPZGJSEDRMUAW-VJDCAHTMSA-N

SMILES

[H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@@]3([H])[C@]([C@@H]([C@@](OC)=O)[C@@H](O)CC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.82 20 with gentle warming

Preparing Stock Solutions for Yohimbine hydrochloride

The following data is based on the product molecular weight 390.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.79 mL 63.95 mL 127.91 mL
1 mM 2.56 mL 12.79 mL 25.58 mL
2 mM 1.28 mL 6.40 mL 12.79 mL
10 mM 0.26 mL 1.28 mL 2.56 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 52 publications citing the usage of this product.

Product Documents for Yohimbine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Yohimbine hydrochloride

For research use only

Citations for Yohimbine hydrochloride

Customer Reviews for Yohimbine hydrochloride (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Yohimbine hydrochloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Chronic yohimbine stress increases vulnerability to reinstatement of palatable food seeking
    Name: Kevin Ball
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 01/25/2019
    To model chronic stress, rats were injected daily with yohimbine (0.0, 2.5, or 5.0 mg/kg; i.p.) during the first 7 days of extinction from palatable food self-administration. Injections were combined with SCH-23390 (0.0, 5.0, or 10.0 μg/kg; i.p.), a dopamine D1-like receptor antagonist. Rats were then tested for reinstatement of food seeking triggered by acute yohimbine (0.0, 1.0, or 2.0 mg/kg; i.p.) and pellet priming. Rats treated previously with chronic yohimbine displayed increased responding following acute yohimbine and pellet priming relative to non-chronically stressed rats under certain conditions. SCH-23390 combined with repeated yohimbine injections attenuated these effects.
    Yohimbine hydrochloride 1127

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All