Yohimbine hydrochloride

  ( 18 citations )    
Product Datasheet
Catalog Number:1127
Chemical Name:17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride
Product Details
Citations (18)
Supplemental Products
Biological Activity
α2-adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors respectively).

Diastereomer also available.

Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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The citations listed below are publications that use Tocris products. Selected citations for Yohimbine hydrochloride include:

18 Citations: Showing 1 - 10
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  1. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels.
    Authors: Delaney and Crane
    Sci Rep  2016;6:19255
  2. Nucleus incertus Orexin2 receptors mediate alcohol seeking in rats
    Authors: Kastman Et al.
    Neuropharmacology  2016;110:82
  3. The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations.
    Authors: Scardochio Et al.
    Front Behav Neurosci  2015;9:331
  4. A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health.
    Authors: Soty Et al.
    Psychopharmacology (Berl)  2015;4:106
  5. Psychopharmacological characterisation of the successive negative contrast effect in rats.
    Authors: Phelps Et al.
    Proc Natl Acad Sci U S A  2015;232:2697
  6. PTSD-like memory generated through enhanced noradrenergic activity is mitigated by a dual step pharmacological intervention targeting its reconsolidation.
    Authors: Gazarini Et al.
    Int J Neuropsychopharmacol  2015;18
  7. A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity.
    Authors: Dudek Et al.
    PLoS One  2015;10:e0141327
  8. The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input.
    Authors: Drake Et al.
    J Physiol  2014;592:3611
  9. Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat.
    Authors: Ciccocioppo Et al.
    Neuropsychopharmacology  2014;39:2601
  10. Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats.
    Authors: Costello Et al.
    Neuropsychopharmacology  2014;39:1843
  11. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
    Authors: Corcoran Et al.
    Mol Metab  2014;34:51
  12. Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons.
    Authors: Mondal Et al.
    PLoS One  2013;8:e60365
  13. Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine.
    Authors: Gozzi Et al.
    Neuropsychopharmacology  2013;38:2120
  14. Relaxin-3/RXFP3 system regulates alcohol-seeking.
    Authors: Ryan Et al.
    Proc Natl Acad Sci U S A  2013;110:20789
  15. Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation.
    Authors: Kim Et al.
    Brain Res  2011;1384:110
  16. The genetic design of signaling cascades to record receptor activation.
    Authors: Barnea Et al.
    Proc Natl Acad Sci U S A  2008;105:64
  17. Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors.
    Authors: Maupoil Et al.
    Br J Pharmacol  2007;150:899
  18. Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.
    Authors: Marchese Et al.
    Br J Pharmacol  2003;140:520
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