Catalog Number: 1127
Chemical Name: 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride
Biological Activity
α2-adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors respectively).

Diastereomer also available.

Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Comparison of the α-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine.
    Doxey et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1984;325:136
  2. A re-evaluation of the role of α2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat.
    Redfern and Williams
    Br.J.Pharmacol., 1995;116:2081
  3. Yohimbine dimers exhibiting selectivity for the human α2c-adrenoceptor subtype.
    Lalchandani et al.
    J.Pharmacol.Exp.Ther., 2002;303:979
  4. Yohimbine: a pharmacological probe for study of the α2-adrenoceptor.
    Goldberg and Robertson
    Pharmacol.Rev., 1987;35:143

The citations listed below are publications that use Tocris products. Selected citations for Yohimbine hydrochloride include:

17 Citations: Showing 1 - 10
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  1. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels.
    Authors: Delaney and Crane
    Sci Rep 2016;6:19255
  2. Nucleus incertus Orexin2 receptors mediate alcohol seeking in rats
    Authors: Kastman Et al.
    Neuropharmacology 2016;110:82
  3. The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations.
    Authors: Scardochio Et al.
    Front Behav Neurosci 2015;9:331
  4. A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health.
    Authors: Soty Et al.
    Psychopharmacology (Berl) 2015;4:106
  5. Psychopharmacological characterisation of the successive negative contrast effect in rats.
    Authors: Phelps Et al.
    Proc Natl Acad Sci U S A 2015;232:2697
  6. PTSD-like memory generated through enhanced noradrenergic activity is mitigated by a dual step pharmacological intervention targeting its reconsolidation.
    Authors: Gazarini Et al.
    Int J Neuropsychopharmacol 2015;18
  7. A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity.
    Authors: Dudek Et al.
    PLoS One 2015;10:e0141327
  8. The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input.
    Authors: Drake Et al.
    J Physiol 2014;592:3611
  9. Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat.
    Authors: Ciccocioppo Et al.
    Neuropsychopharmacology 2014;39:2601
  10. Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats.
    Authors: Costello Et al.
    Neuropsychopharmacology 2014;39:1843
  11. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
    Authors: Corcoran Et al.
    Mol Metab 2014;34:51
  12. Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons.
    Authors: Mondal Et al.
    PLoS One 2013;8:e60365
  13. Relaxin-3/RXFP3 system regulates alcohol-seeking.
    Authors: Ryan Et al.
    Proc Natl Acad Sci U S A 2013;110:20789
  14. Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation.
    Authors: Kim Et al.
    Brain Res 2011;1384:110
  15. The genetic design of signaling cascades to record receptor activation.
    Authors: Barnea Et al.
    Proc Natl Acad Sci U S A 2008;105:64
  16. Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors.
    Authors: Maupoil Et al.
    Br J Pharmacol 2007;150:899
  17. Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.
    Authors: Marchese Et al.
    Br J Pharmacol 2003;140:520
Expand to show all 17 Citations

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