Recombinant Human RCAN1 Protein

Name: Recombinant Human RCAN1 Protein
Brand: Novus Biologicals
SKU: NBC1-18339
Price: 419 USD
Availability: InStock

Novus Biologicals | Catalog # NBC1-18339

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Source

E. coli

Applications

SDS-PAGE

View all RCAN1 Proteins and Enzymes »

Product Specifications

Description

An un-tagged recombinant protein corresponding to the amino acids 1-117 of Human RCAN1

Source: E.coli

Amino Acid Sequence: MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS

Purity

>90%, by SDS-PAGE

Predicted Molecular Mass

13.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human RCAN1 Protein

SDS-PAGE: Recombinant Human RCAN1 Protein [NBC1-18339]

SDS-Page: RCAN1 Protein [NBC1-18339] - DSCR isoform b, 13kDa (117aa), confirmed by MALDI-TOF with a purity of 90% by SDS - PAGE

Formulation, Preparation, and Storage

NBC1-18339

Formulation	20mM Tris-HCl buffer (pH 7.5), 0.1M NaCl, 1mM DTT, 10% Glycerol
Preservative	No Preservative
Concentration	1 mg/ml
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RCAN1

The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E.coli and purified by using conventional chromatography techniques.

Alternate Names

Adapt78, calcipressin-1, calcium and oxidant-inducible mRNA, Down syndrome candidate region 1, Down syndrome critical region gene 1, Down syndrome critical region protein 1, DSC1, modulatory calcineurin-interacting protein 1, Myocyte-enriched calcineurin-interacting protein 1, near DSCR proline-rich protein, regulator of calcineurin 1CSP1DSCR1MCIP1RCN1

Gene Symbol

RCAN1

Additional RCAN1 Products

Product Documents for Recombinant Human RCAN1 Protein

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Certificate of Analysis

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Product Specific Notices for Recombinant Human RCAN1 Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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