Recombinant Human alpha-Synuclein Protein, CF Summary
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||X mg/ml (X μM) in 50 mM HEPES pH 7.5, 100 mM NaCl, 1 mM DTT|
|Shipping||The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
0.5 μg and 1 μg per lane of Recombinant Human alpha-Synuclein (Catalog # SP-485) was resolved with SDS-PAGE under reducing conditions and visualized by colloidal Coomassie Blue staining, showing a single band at 19 kDa.
alpha -Synuclein is a member of a family of small, soluble proteins that also include beta -, and gamma -Synuclein.
alpha -Synuclein is predominantly expressed in neurons of the central nervous system, specifically in the presynaptic region of nerve terminals. This protein cycles between a free, partially unfolded form and a helical, membrane-bound form. alpha -Synuclein can aggregate in vivo and in vitro, forming various oligomeric species and fibrillar and amorphous aggregates. The fibrils and amyloidal forms are major components of Lewy Bodies and have been linked to the pathogenesis of Parkinson's disease dementia. alpha -Synuclein aggregates can also be found associated with amyloid plaques in Alzheimer's disease.
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- Chen R.H. et al. (2013) J. Biol. Chem. 288: 7438
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- Surguchov A. (2008) Int Rev Cell Mol. Biol. 270: 225
- Xia Q. et al. (2008) Front Biosci. 13: 3850
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