Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Annexin A10
Human Annexin A10
(ANXA10), also known as Annexin 10 or Annexin-14, is
a 37 kDa member of the Annexin family (1), which
are calcium-dependent phospholipid-binding proteins preferentially being
located on the cytosolic face of the plasma membrane. The Annexins consist of a
unique N-terminal domain followed by a homologous C-terminal core domain
containing the phospholipid-binding sites. The C-terminal domain is comprised
of four 60‑70 aa annexin repeats which form a tightly packed disc known as the
annexin domain. Members of the Annexin family play a role in cytoskeletal
interactions, phospholipase inhibition, regulation of cellular growth, and
intracellular signal transduction pathways (2).
Human Annexin A10 shares approximately
89% and 88% aa sequence identity with mouse and rat Annexin A10 respectively.
Morgan, R. et al. (1999) Genomics 60:40.
Gerke, V. et al. (2005) Nat. Rev. Mol. Cell Biol. 6:449.
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