Recombinant Human Cadherin-9 Fc Chimera Protein, CF

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Recombinant Human Cadherin-9 Fc Chimera Protein Binding Activity
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Product Details

Recombinant Human Cadherin-9 Fc Chimera Protein, CF Summary

Product Specifications

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Measured by its binding ability in a functional ELISA. When Recombinant Human Cadherin-9 Fc Chimera is immobilized at 1 μg/mL, 100 μL/well, Recombinant Human Cadherin‑6/KCAD Fc Chimera (Catalog # 2715-CA) binds with an ED50 of 0.6-3.6 μg/mL. 
Human embryonic kidney cell, HEK293-derived human Cadherin-9 protein
Human Cadherin-9
Accession # Q9ULB4
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
89.1 kDa
92-106 kDa, under reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
  • 12 months from date of receipt, ≤ -20 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, ≤ -20 °C under sterile conditions after reconstitution.

Scientific Data

Binding Activity Recombinant Human Cadherin-9 Fc Chimera Protein Binding Activity View Larger

When Recombinant Human Cadherin 9 Fc Chimera is immobilized at 1 µg/mL, 100 µL/well, Recombinant Human Cadherin-6/KCAD Fc Chimera (Catalog # 2715-CA) binds with an ED50 of 0.6-3.6 µg/mL.

SDS-PAGE Recombinant Human Cadherin-9 Fc Chimera Protein SDS-PAGE View Larger

2 μg/lane of Recombinant Human Cadherin-9 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 92-106 kDa and 180-210 kDa, respectively.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: Cadherin-9

Cadherin-9 (CDH9) is a member of the larger Cadherin superfamily of cell surface glycoproteins originally identified as proteins mediating cell-cell adhesion (1). In humans, there are more than 100 cadherin members divided into distinct families and numerous sub-families (1-3). Cadherins share a general structural architecture with an extracellular domain (ECD) containing 2 or more extracellular Ca2+ binding cadherin repeat (EC) domains, a single-pass transmembrane section, and a short cytoplasmic tail (1-3). Cadherins function by forming homophilic binding interactions through these EC domains to generate both trans and cis dimers (1-3). Human CDH9 is categorized as a classical cadherin, containing 5 EC domains, and the ECD shares 94% amino acid sequence identity with the ECD of both mouse and rat CDH9, respectively. Cadherins are found in diverse cell types and have been implicated as essential for the morphogenesis and homeostasis of multiple tissues and organs (1-3). Human CDH9 functions primarily in the central nervous system and is expressed in DG and CA3 neurons. Loss of CDH9 expression leads to defects in synapse formation and differentiation of specific neural circuits. (4). Additionally, disruption to CDH9 and CDH10 genes has been linked to autism spectrum disorders (5, 6). CDH9 expression has been identified in human kidney, and it has been used as a cell surface marker for fibroblasts (7). Recently, CDH9 has been reported as a potential suppressor of cancer metastasis (8).

  1. Gumbiner, B.M. (2005) Nat. Rev. Mol. Cell Biol. 6:622.
  2. Hirano S and Takeichi M. (2012) Physiol Rev. Apr; 92(2):597.
  3. Nollet et al. (2000) J Mol Biol. Jun. 9; 299(3):551.
  4. Williams ME et al. (2011) Neuron. Aug. 25; 71(4):640.
  5. Wang K. et al. (2009) Nature 459, 528.
  6. Inoue YU and, Inoue T. (2016) Sci Rep. 6:31227.
  7. Thedieck, C. et al. (2007) PLoS One. 2(8):e657.
  8. Yan G. et al. (2017) Scientific Reports volume 7, 10023.
Entrez Gene IDs
1007 (Human); 12565 (Mouse); 29163 (Rat)
Alternate Names
cadherin 9, type 2 (T1-cadherin); Cadherin9; Cadherin-9; CDH9; T1-Cadherin


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