Recombinant Human CD82 Fc Chimera Protein, CF Summary
Accession # P27701
2 μg/lane of Recombinant Human CD82/Kai-1 Fc Chimera was resolved with SDS-PAGE underreducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Bluestaining, showing bands at 53-65 kDa and 105-130 kDa, respectively.
CD82 antigen, also known as Kai-1, C33 and TSPAN27, is a widely expressed palmitoylated molecule of the tetraspanin superfamily (1, 2). The general architecture of tetraspanins contain four transmembrane domains, two extracellular loops, a small inner cytoplasmic loop, and intra-cellular N and C termini (1). One of the extracellular loops is termed the large extracellular loop (LEL) and it is responsible for interactions with binding partners such as integrins. Within the LEL, human CD82/Kai-1 shares 65% and 63%amino acid (aa) sequence identity with mouse and rat CD82/Kai-1, respectively. CD82/Kai-1 is a component of the promiscuous TIMP-1 interacting protein complex on the cell surface of human adenocarcinoma cells and gives insight into tumorigenic metastatic potential (3). CD82/Kai-1 suppresses EMT in prostate cancer cells adhered to fibronectin leading to reduced cell migration and invasiveness (4). CD82/Kai-1 function is important for muscle stem cell function in muscular disorders (5). Overexpression of CD82/Kai-1 suppresses growth, migration and invasion of oral cancer cells and may be considered as a potential therapeutic target in oral cancer (6).
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- Chai, J. et al. (2017) Mol Med. Rep. April; 15:1527.
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