Recombinant Human Fc alpha/mu R His-tag Protein, CF

R&D Systems | Catalog # 9278-FC

R&D Systems
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Key Product Details

  • R&D Systems CHO-derived Recombinant Human Fc alpha/mu R His-tag Protein (9278-FC)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

CHO

Accession Number

Q8WWV6

Applications

Bioactivity
View all Fc alpha/mu R Proteins and Enzymes »

Product Specifications

Source

Chinese Hamster Ovary cell line, CHO-derived human Fc alpha/mu R protein
Leu17-Arg450, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Leu17

Predicted Molecular Mass

47 kDa

SDS-PAGE

84-108 kDa, reducing conditions

Activity

Measured by its binding ability in a functional ELISA.
When Human IgM is immobilized at 2.5 μg/mL, 100 μL/well, the concentration of Recombinant Human Fc alpha /μ R that produces 50% of the optimal binding response is approximately 0.12-0.72 μg/mL.

Reviewed Applications

Read 1 review rated 5 using 9278-FC in the following applications:

Formulation, Preparation, and Storage

9278-FC
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution

Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Fc alpha/mu R

Fc alpha/mu Receptor (FCAMR), designated CD351, is an approximately 60 kDa transmembrane protein that serves as a receptor for IgA and IgM immunoglobulins (1). Mature human FCAMR consists of a 434 amino acid (aa) extracellular domain with one Ig-like domain, a 21 aa transmembrane segment, and a 61 aa cytoplasmic domain (2). Within the ECD, human FCAMR shares 51% aa sequence identity with mouse and rat FCAMR. Alternative splicing generates additional isoforms that are truncated following the Ig-like domain, are truncated before the transmembrane segment, or carry a 9 aa deletion and a substitution of the transmembrane segment. FCAMR is expressed on B cells, macrophages, and kidney mesangial cells (2-4). It binds to both IgA and IgM in immune complexes but not to monomeric immunoglobulin (2, 5). FCAMR participates in pathogen clearance as well as foam cell formation by mediating the internalization of IgM-opsonized microbes and oxidized LDL-containing particles (2, 6).

References

  1. Wang, H. et al. (2016) Front. Immunol. 7:99.
  2. Shibuya, A. et al. (2000) Nat. Immunol. 1:441.
  3. Matesanz-Isabel, J. et al. (2011) Immunol. Lett. 134:104.
  4. McDonald, K.J. et al. (2002) Biochem. Biophys. Res. Commun. 290:438.
  5. Ghumra, A. et al. (2009) Eur. J. Immunol. 39:1147.
  6. Feng, X. et al. (2010) Atherosclerosis 208:396.

Long Name

Fc alpha/mu Receptor

Alternate Names

CD351, FCA/MR, FCAMR, FKSG87, uR

Entrez Gene IDs

83953 (Human); 64435 (Mouse); 681070 (Rat)

Gene Symbol

FCAMR

UniProt

Q8WWV6

Additional Fc alpha/mu R Products

Product Documents for Recombinant Human Fc alpha/mu R His-tag Protein, CF

Certificate of Analysis

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Product Specific Notices for Recombinant Human Fc alpha/mu R His-tag Protein, CF

For research use only

Citations for Recombinant Human Fc alpha/mu R His-tag Protein, CF

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