Recombinant Human Follistatin-like 5/FSTL5 (Catalog # 9066-FN) inhibits Hep3B human hepatocellular carcinoma cell survival. The ED50 for this effect is 3-12 μg/mL.
Background: Follistatin-like 5/FSTL5
Follistatin-like 5 (FSTL5) is a secreted 94 kDa (predicted) member of the SPARC protein family (1). In its N-terminal half, FSTL5 contains a Kazal-like domain, two EF-hand domains, and two Ig-like domains. Mature human FSTL5 shares 91% amino acid sequence identity with mouse and rat FSTL5. Alternative splicing generates an isoform with a 10 residue deletion following the second Ig-like domain. FSTL5 is expressed in the cartilage and tendon of developing digits and the shafts of long bones (2). In the brain it is expressed in the olfactory bulb, CA3 area of the hippocampus, and granule cell layer of the cerebellum (3). FSTL5 inhibits the proliferation and promotes the apoptosis of hepatocellular carcinoma cells (4). Its expression in medulloblastoma and down-regulation in hepatocellular carcinoma are associated with poor prognosis (4, 5).
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Entrez Gene IDs:
56884 (Human); 213262 (Mouse); 365823 (Rat)
Follistatin like 5; Follistatin-like 5; Follistatin-like protein 5; follistatin-related protein 5; FSL5; FSTL5; KIAA1263DKFZp566D234
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