Recombinant Human mGluR4 Protein, CF

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Recombinant Human mGluR4 Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Bioassay data are not available.
Chinese Hamster Ovary cell line, CHO-derived human mGluR4 protein
Lys33-Ser518, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
55 kDa
62-76 kDa, reducing conditions

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: mGluR4

Metabotropic glutamate receptors (mGluRs) are members of the G-protein-coupled receptor (GPCR) superfamily, modulating glutamate neurotransmission in the central and peripheral nervous systems through GTP-binding proteins (1). Structurally, members of this family are characterized by a large N-terminal extracellular domain (ECD), seven transmembrane domain, and a cytoplasmic C-terminal domain that is variable in length. Two ECDs dimerize together and large conformational changes are induced when agonists bind to one or both domains (2). The C-terminal region is subject to alternative splicing, regulation by phosphorylation and interacts directly with a G-protein to modulate protein-protein interactions (2, 3). The receptors are subdivided into three groups (I–III) based on sequence homology, signal transduction and pharmacological properties (1, 2). The Group III receptors include mGLuRs 4, 6, 7 and 8 (2). mGLuR4 has been shown to be expressed postsynaptically in certain areas such as the hippocampus and retina (4). Mature human mGluR4 is 880 amino acids in length. In the ECD region comprising amino acids (aa) 33-587, human mGluR4 shares 97% aa sequence identity with mouse and rat mGluR4.

  1. Conn P.J. et al. (1997) Annu. Rev. Pharmacol. Toxicol. 37:205.
  2. Niswender C.M. et al. (2010) Annu. Rev. Pharmacol. Toxicol. 5:295.
  3. Pin J.P. et al. (1995) Neuropharmacology. 34:1.
  4. Bradley, S.R. et al. (1996) J. Neurosci. 16:2044.
Long Name
Metabotropic Glutamate Receptor 4
Entrez Gene IDs
2914 (Human); 268934 (Mouse); 24417 (Rat)
Alternate Names
glutamate receptor, metabotropic 4; GPRC1D; GPRC1Dmetabotropic glutamate receptor 4; GRM4; MGC177594; mGlu4; mGluR4; MGLUR4glutamate metabotropic receptor 4


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