Recombinant Human OSMR beta Protein, CF

Catalog # Availability Size / Price Qty
R&D Systems Recombinant Proteins and Enzymes
1 Image
Product Details
Citations (1)
Supplemental Products

Recombinant Human OSMR beta Protein, CF Summary

Product Specifications

>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its ability to bind rhOSM in the presence of rhgp130 in a functional ELISA.
Mouse myeloma cell line, NS0-derived human OSM R beta protein
Accession #
N-terminal Sequence
Predicted Molecular Mass
81 kDa
120-140 kDa, reducing conditions

Product Datasheets

You must select a language.



Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: OSMR beta

OSM R beta is a 150 - 180 kDa member of the IL-6 receptor family. It associates with gp130 to form the type II OSM receptor that is responsive to OSM. The gp130 subunit is shared by other IL-6 family cytokine receptors (1, 2, 3, 4), and OSM R beta associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31 (5, 6). The human OSM R beta cDNA encodes a 979 amino acid (aa) precursor that includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aa transmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three fibronectin type-III domains. The cytoplasmic domain contains box1, 2, and 3 motifs (7). Within the ECD, human OSM R beta shares 55%, 58%, 61%, and 72% aa sequence identity with mouse, rat, bovine, and canine OSM R beta, respectively. It also shares 31% aa sequence identity with human LIF R, but less than 20% aa sequence identity with human CNTF R alpha, G-CSF R, IL-6 R, IL-11 R alpha, and TCCR. OSM R beta does not bind cytokines directly, but increases the affinity of gp130 for OSM, and GPL for IL-31 (7, 8). OSM R beta, gp130, and GPL each initiate signaling events following ligand stimulation (9, 10). Jak/STAT and MAPK pathways are activated by OSM R beta -containing receptors (9, 11, 12, 13), including STAT5b and SHC which are not activated by other IL-6 family receptors (10, 13). In mice, the loss of OSM R beta expression blocks erythroid progenitor development in bone marrow, and dramatically reduces the number of circulating platelets and erythrocytes (14). The type II OSM receptor is the only IL-6 family receptor that promotes osteoblast differentiation in calvaria cell cultures (15).

  1. Chen, S.-H. and E.N. Benveniste (2004) Cytokine Growth Factor Rev. 15:379. 
  2. Heinrich, P.C. et al. (2003) Biochem. J. 374:1. 
  3. Tanaka, M. and A. Miyajima (2003) Rev. Physiol. Biochem. Pharmacol. 149:39. 
  4. Gearing, D.P. et al. (1992) Science 255:1434. 
  5. Dillon, S.R. et al. (2004) Nat. Immunol. 5:752. 
  6. Diveu, C. et al. (2003) J. Biol. Chem. 278:49850.  
  7. Mosley, B. et al. (1996) J. Biol. Chem. 271:32635. 
  8. Diveu, C. et al. (2004) Eur. Cytokine Netw. 15:291.
  9. Dreuw, A. et al. (2004) J. Biol. Chem. 279:36112.
  10. Wang, Y. et al. (2000) J. Biol. Chem. 275:25273.
  11. Hermanns, H.M. et al. (2000) J. Biol. Chem. 275:40742.
  12. Kuropatwinski, K.K. et al. (1997) J. Biol. Chem. 272:15135.
  13. Auguste, P. et al. (1997) J. Biol. Chem. 272:15760.
  14. Tanaka, M. et al. (2003) Blood 102:3154.
  15. Malaval, L. et al. (2005) J. Cell. Physiol. 204:585.
Long Name
Oncostatin M Receptor beta
Entrez Gene IDs
9180 (Human); 18414 (Mouse); 310132 (Rat)
Alternate Names
IL-31 receptor subunit beta; IL-31R subunit beta; IL-31RB; IL-31R-beta; Interleukin-31 receptor subunit beta; MGC150627; MGC75127; oncostatin M receptor; oncostatin-M specific receptor beta subunit; oncostatin-M-specific receptor subunit beta; OSM R beta; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1

Citation for Recombinant Human OSMR beta Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor.
    Authors: Chollangi, Srinivas, Mather, Timothy, Rodgers, Karla K, Ash, John D
    J Biol Chem, 2012;287(39):32848-59.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA (Capture)


No product specific FAQs exist for this product, however you may

View all Proteins and Enzyme FAQs

Reconstitution Buffers

Reviews for Recombinant Human OSMR beta Protein, CF

There are currently no reviews for this product. Be the first to review Recombinant Human OSMR beta Protein, CF and earn rewards!

Have you used Recombinant Human OSMR beta Protein, CF?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review