Recombinant Mouse ICAM-2/CD102 Fc Chimera Protein, CF
Recombinant Mouse ICAM-2/CD102 Fc Chimera Protein, CF Summary
Optimal dilutions should be determined by each laboratory for each application.
Accession # P35330
|DIEGRMD||Human IgG1 |
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in Tris, Citric Acid and NaCl.|
|Reconstitution||Reconstitute at 0.4 mg/mL in sterile PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Intercellular Adhesion Molecule-2 (ICAM-2, CD102), a member of the immunoglobulin superfamily, binds the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). ICAM-2 is constitutively expressed at high levels on vascular endothelial cells and lymphohematopoietic cells. ICAM-2 mediated adhesion has been shown to provide a co-stimulatory signal for T cell aggregation, NK cytotoxicity and NK cell migration. The mouse and human ICAM-2 proteins share 60% amino acid identity. Human LFA-1 binds equally well to human or mouse ICAM-2.
- Somersalo, K. et al. (1995) J. Biol. Chem. 270:8629.
- Hayflick, J. et al. (1998) Immunologic Res. 17:313.
- Xu, H. (1992) J. Immunol. 149:2650.
Citations for Recombinant Mouse ICAM-2/CD102 Fc Chimera Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia
Authors: S Paetau, T Rolova, L Ning, CG Gahmberg
Front Mol Neurosci, 2017-12-22;10(0):431.
Sample Types: Whole Cells
ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo.
Authors: Halai, Krishma, Whiteford, James, Ma, Bin, Nourshargh, Sussan, Woodfin, Abigail
J Cell Sci, 2013-12-06;127(0):620-9.
Sample Types: Whole Cells
Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin.
Authors: Furutani Y, Kawasaki M, Matsuno H, Mitsui S, Mori K, Yoshihara Y
J Biol Chem, 2012-09-27;287(46):39041-9.
Applications: Surface Plasmon Resonance
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