Recombinant Mouse IL-7 Protein

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Formulations:
Catalog # Availability Size / Price Qty
407-ML-005
407-ML-025
407-ML-200
Recombinant Mouse IL-7 Protein Data
2 Images
Product Details
Citations (75)
FAQs
Reviews (3)

Recombinant Mouse IL-7 Protein Summary

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL). Yokota, T. et al. (1986) Proc. Natl. Acad. Sci. USA 83:5894. The ED50 for this effect is 0.15-0.3 ng/mL.
Source
E. coli-derived mouse IL-7 protein
Glu26-Ile154, with an N-terminal Met
Accession #
N-terminal Sequence
Analysis
Glu26
Predicted Molecular Mass
15 kDa

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

407-ML

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

407-ML/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute 5 µg vials at 50 µg/mL in sterile PBS. Reconstitute 25 µg or larger vials at 100 µg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Bioactivity View Larger

Recombinant Mouse IL-7 (Catalog # 407-ML) stimulates cell proliferation of PHA-activated human peripheral blood lymphocytes. The ED50for this effect is 0.15-0.3 ng/mL.

SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse IL-7 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-7

IL-7 (interleukin-7) is a 25 kDa cytokine of the hemopoietin family that plays important roles in lymphocyte differentiation, proliferation, and survival (1-4). Mouse IL-7 cDNA encodes 154 amino acids (aa) that include a 25 aa signal peptide (4). Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. Human and mouse IL-7 exhibit cross-species activity (2, 3). IL-7 is produced by a wide variety of cells in primary and secondary lymphoid tissues, including stromal epithelial cells of the thymus, bone marrow, and intestines (1, 2, 5). Circulating IL-7 is limiting in healthy animals, but increases during lymphopenia (1, 6). IL-7 signals through a complex of the IL-7 Receptor alpha subunit (IL-7 R alpha, also known as CD127) with the common gamma chain ( gamma c) (1). The gamma c is also a subunit of the receptors for IL-2, -4, -9, -15, and -21 (1). IL-7 R alpha is expressed on double negative (CD4-CD8-) and CD4+ or CD8+ single positive naïve and memory T cells, but undergoes IL-7-mediated down‑regulation and shedding during antigen-driven T cell proliferation, and is absent on regulatory T cells (1, 2, 6-11). IL-7 contributes to the maintenance of all naïve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2 (9-11). It is required for optimal T cell-dendritic cell interaction (6). IL-7 is expressed early in B cell development prior to the appearance of surface IgM (1, 5, 9). In mouse, IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development, while in humans, it is required for T cell but not for B cell development (4, 9, 12, 13). However, IL-7 functions in both mouse and human pro-B cells to suppress premature Ig light chain recombination during proliferative growth (14, 15).

References
  1. Sasson, S.C. et al. (2006) Curr. Drug Targets 7:1571.
  2. Barata, J.T. et al. (2006) Exp. Hematol. 34:1133.
  3. Goodwin, R.G. et al. (1990) Proc. Natl. Acad. Sci. USA 86:302.
  4. Namen, A.E. et al. (1988) Nature 333:571.
  5. Shalapour, S. et al. (2012) PLoS ONE 7: e31939.
  6. Saini, M. et al. (2009) Blood 113:5793.
  7. Park, J.H. et al. (2004) Immunity 21:289.
  8. Vranjkovic, A. et al. (2007) Int. Immunol. 19:1329.
  9. Sudo, T. et al. (1993) Proc. Natl. Acad. Sci. 90:9125.
  10. Seddon, B. et al. (2003) Nat. Immunol. 4:680.
  11. Schluns, K.S. et al. (2000) Nat. Immunol. 5:426.
  12. Peschon, J.J. et al. (1994) J. Exp. Med. 180:1955.
  13. Pribyl, J.A. and T.W. LeBien (1996) Proc. Natl. Acad. Sci. 93:10348.
  14. Johnson, K. et al. (2012) J. Immunol. 188:6084.
  15. Nodland, S.E. et al. (2011) Blood 118:2116.
Long Name
Interleukin 7
Entrez Gene IDs
3574 (Human); 16196 (Mouse); 25647 (Rat)
Alternate Names
IL7; IL-7; IL-7interleukin-7; interleukin 7; Lymphopoietin-1; PBGF

Citations for Recombinant Mouse IL-7 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

75 Citations: Showing 1 - 10
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  1. Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells
    Authors: S Steinmann, M Schoedsack, F Heinrich, PC Breda, A Ochel, G Tiegs, K Neumann
    Sci Rep, 2020;10(1):1071.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  2. T Cell Activation Depends on Extracellular Alanine
    Authors: N Ron-Harel, JM Ghergurovi, G Notarangel, MW LaFleur, Y Tsubosaka, AH Sharpe, JD Rabinowitz, MC Haigis
    Cell Rep, 2019;28(12):3011-3021.e4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
    Authors: S Goossens, J Wang, C Tremblay, J De Medts, S T'Sas, T Nguyen, J Saw, K Haigh, DJ Curtis, P Van Vlierb, G Berx, T Taghon, JJ Haigh
    Haematologica, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells
    Authors: DM Previte, CP Martins, EC O'Connor, ML Marre, GM Coudriet, NW Beck, AV Menk, RH Wright, HM Tse, GM Delgoffe, JD Piganelli
    Cell Rep, 2019;27(1):129-141.e4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. High activation of STAT5A drives peripheral T-cell lymphoma and leukemia
    Authors: B Maurer, H Nivarthi, B Wingelhofe, HTT Pham, M Schlederer, T Suske, R Grausenbur, AI Schiefer, M Prchal-Mur, D Chen, S Winkler, O Merkel, C Kornauth, M Hofbauer, B Hochgatter, G Hoermann, A Hoelbl-Kov, J Prochazkov, C Lobello, AA Cumaraswam, J Latzka, M Kitzwögere, A Chott, A Janikova, Š Pospíšilov, JI Loizou, S Kubicek, P Valent, T Kolbe, F Grebien, L Kenner, PT Gunning, R Kralovics, M Herling, M Müller, T Rülicke, V Sexl, R Moriggl
    Haematologica, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function
    Authors: C Konopacki, Y Pritykin, Y Rubtsov, CS Leslie, AY Rudensky
    Nat. Immunol., 2019;20(2):232-242.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis
    Authors: M Mandal, MK Okoreeh, DE Kennedy, M Maienschei, J Ai, KC McLean, N Kaverina, M Veselits, I Aifantis, F Gounari, MR Clark
    Nat. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors
    Authors: ELY Chen, PK Thompson, JC Zúñiga-Pfl
    Nat. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions
    Authors: PT Mantani, P Dunér, I Ljungcrant, J Nilsson, H Björkbacka, GN Fredrikson
    BMC Immunol., 2019;20(1):47.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells
    Authors: A Seki, S Rutz
    J. Exp. Med., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  11. Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing
    Authors: Y Ouchi, A Patil, Y Tamura, H Nishimasu, A Negishi, SK Paul, N Takemura, T Satoh, Y Kimura, M Kurachi, O Nureki, K Nakai, H Kiyono, S Uematsu
    Int. Immunol., 2018;30(4):141-154.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Hyaluronan-binding by CD44 reduces the memory potential of activated murine CD8 T cells
    Authors: SSM Lee-Sayer, N Maeshima, MN Dougan, A Dahiya, AA Arif, M Dosanjh, CA Maxwell, P Johnson
    Eur. J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. The common ?-chain cytokine IL-7 promotes immunopathogenesis during fungal asthma
    Authors: KM Reeder, CW Dunaway, JP Blackburn, Z Yu, S Matalon, AT Hastie, EJ Ampleford, DA Meyers, C Steele
    Mucosal Immunol, 2018;11(5):1352-1362.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  14. Microenvironment-derived ADAM28 prevents cancer dissemination
    Authors: C Gérard, C Hubeau, O Carnet, M Bellefroid, NE Sounni, S Blacher, G Bendavid, M Moser, R Fässler, A Noel, D Cataldo, N Rocks
    Oncotarget, 2018;9(98):37185-37199.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene
    Authors: S Kojo, N Yasmin, S Muroi, M Tenno, I Taniuchi
    Nat Commun, 2018;9(1):3593.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Stimulation
  16. mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
    Authors: SK Martin, S Fitter, N El Khawank, RH Grose, CR Walkley, LE Purton, MA Ruegg, MN Hall, S Gronthos, ACW Zannettino
    Sci Rep, 2018;8(1):14501.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Tissue signals imprint ILC2 identity with anticipatory function
    Authors: RR Ricardo-Go, SJ Van Dyken, C Schneider, J Lee, JC Nussbaum, HE Liang, D Vaka, WL Eckalbar, AB Molofsky, DJ Erle, RM Locksley
    Nat. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms
    Authors: M Yamaguchi, SK Samuchiwal, O Quehenberg, JA Boyce, B Balestrier
    Mucosal Immunol, 2018;11(3):615-626.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down-regulating mTOR signaling in a mouse hepatocellular carcinoma model
    Authors: K Dai, Y Huang, Z Chen, X Sun, L Yang, Y Jiang
    Eur. J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Infection exposure promotes ETV6-RUNX1 precursor B cell leukemia via impaired H3K4 demethylases
    Authors: G Rodríguez-, J Hauer, A Martín-Lor, D Schäfer, C Bartenhage, I García-Ram, F Auer, I Gonzalez-H, L Ruiz-Roca, M Gombert, V Okpanyi, U Fischer, C Chen, M Dugas, S Bhatia, RM Linka, M Garcia-Suq, MV Rascón-Tri, A Garcia-San, O Blanco, MB Garcia-Cen, FJ Garcia-Cri, C Cobaleda, D Alonso-Lóp, J De Las Riv, M Müschen, C Vicente-Du, I Sánchez-Ga, A Borkhardt
    Cancer Res., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
    Authors: A Wallrapp, SJ Riesenfeld, PR Burkett, RE Abdulnour, J Nyman, D Dionne, M Hofree, MS Cuoco, C Rodman, D Farouq, BJ Haas, TL Tickle, JJ Trombetta, P Baral, CSN Klose, T Mahlakõiv, D Artis, O Rozenblatt, IM Chiu, BD Levy, MS Kowalczyk, A Regev, VK Kuchroo
    Nature, 2017;549(7672):351-356.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors
    Authors: A Itoh-Nakad, M Matsumoto, H Kato, J Sasaki, Y Uehara, Y Sato, R Ebina-Shib, M Morooka, R Funayama, K Nakayama, K Ochiai, A Muto, K Igarashi
    Cell Rep, 2017;18(10):2401-2414.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling
    Authors: MJ de Bruijn, J Rip, EK van der Pl, LW van Greuni, VT Ta, LP Kil, AW Langerak, GF Rimmelzwaa, W Ellmeier, RW Hendriks, OB Corneth
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection
    Authors: HF Moffett, ANR Cartwright, HJ Kim, J Godec, J Pyrdol, T Äijö, GJ Martinez, A Rao, J Lu, TR Golub, H Cantor, AH Sharpe, CD Novina, KW Wucherpfen
    Nat. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1
    Authors: S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra
    Nat. Methods, 2017;14(5):531-538.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice
    Authors: M Han, C Rajput, JY Hong, J Lei, JL Hinde, Q Wu, JK Bentley, MB Hershenson
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. IgH isotype-specific B cell receptor expression influences B cell fate
    Authors: P Tong, A Granato, T Zuo, N Chaudhary, A Zuiani, SS Han, R Donthula, A Shrestha, D Sen, JM Magee, MP Gallagher, CE van der Po, MC Carroll, DR Wesemann
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s
    Authors: Jakob von Moltke
    J. Exp. Med, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis
    Cell Death Dis, 2016;7(11):e2479.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces CD4+ T Cell Anergy via GRAIL.
    Authors: Sande O, Karim A, Li Q, Ding X, Harding C, Rojas R, Boom W
    J Immunol, 2016;196(2):691-702.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development
    Authors: L Zhao, RL Frock, Z Du, J Hu, L Chen, MS Krangel, FW Alt
    J. Exp. Med, 2016;213(9):1921-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.
    Authors: Gerby B, Tremblay C, Tremblay M, Rojas-Sutterlin S, Herblot S, Hebert J, Sauvageau G, Lemieux S, Lecuyer E, Veiga D, Hoang T
    PLoS Genet, 2015;10(12):e1004768.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells.
    Authors: Gandhapudi S, Tan C, Marino J, Taylor A, Pack C, Gaikwad J, Van De Wiele C, Wren J, Teague T
    J Immunol, 2015;194(8):3820-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
    Authors: Hao B, Naik A, Watanabe A, Tanaka H, Chen L, Richards H, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematsu T, Krangel M
    J Exp Med, 2015;212(5):809-24.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
    Authors: Tamehiro N, Oda H, Shirai M, Suzuki H
    PLoS ONE, 2015;10(6):e0131047.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.
    Authors: Lubeck B, Lapinski P, Oliver J, Ksionda O, Parada L, Zhu Y, Maillard I, Chiang M, Roose J, King P
    J Immunol, 2015;195(1):31-5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine.
    Authors: Bando J, Liang H, Locksley R
    Nat Immunol, 2015;16(2):153-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.
    Authors: Marcais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff Y, Gilson E, Vivier E, Walzer T
    Nat Immunol, 2014;15(8):749-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity.
    Authors: Berezhnoy, Alexey, Castro, Iris, Levay, Agata, Malek, Thomas R, Gilboa, Eli
    J Clin Invest, 2014;124(1):188-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  40. Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation.
    Authors: Liu C, Wang H, Yu S, Jin R, Tang H, Liu Y, Ge Q, Sun X, Zhang Y
    J Immunol, 2014;193(2):663-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. A committed precursor to innate lymphoid cells.
    Authors: Constantinides, Michael, McDonald, Benjamin, Verhoef, Philip A, Bendelac, Albert
    Nature, 2014;508(7496):397-401.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma.
    Authors: Green M, Vicente-Duenas C, Romero-Camarero I, Long Liu C, Dai B, Gonzalez-Herrero I, Garcia-Ramirez I, Alonso-Escudero E, Iqbal J, Chan W, Campos-Sanchez E, Orfao A, Pintado B, Flores T, Blanco O, Jimenez R, Martinez-Climent J, Criado F, Cenador M, Zhao S, Natkunam Y, Lossos I, Majeti R, Melnick A, Cobaleda C, Alizadeh A, Sanchez-Garcia I
    Nat Commun, 2014;5(0):3904.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model.
    Authors: Cheadle E, Sheard V, Rothwell D, Bridgeman J, Ashton G, Hanson V, Mansoor A, Hawkins R, Gilham D
    J Immunol, 2014;192(8):3654-65.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Elimination of IL-10-inducing T-helper epitopes from an IGFBP-2 vaccine ensures potent antitumor activity.
    Authors: Cecil D, Holt G, Park K, Gad E, Rastetter L, Childs J, Higgins D, Disis M
    Cancer Res, 2014;74(10):2710-8.
    Species: Mouse
    Sample Types: Whole Cells
  45. The TCR ligand-inducible expression of CD73 marks gammadelta lineage commitment and a metastable intermediate in effector specification.
    Authors: Coffey F, Lee S, Buus T, Lauritsen J, Wong G, Joachims M, Thompson L, Zuniga-Pflucker J, Kappes D, Wiest D
    J Exp Med, 2014;211(2):329-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Aged mice are unable to mount an effective myeloid response to sepsis.
    Authors: Nacionales D, Gentile L, Vanzant E, Lopez M, Cuenca A, Cuenca A, Ungaro R, Li Y, Baslanti T, Bihorac A, Moore F, Baker H, Leeuwenburgh C, Moldawer L, Efron P
    J Immunol, 2014;192(2):612-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
    Authors: Smeets M, DeLuca E, Wall M, Quach J, Chalk A, Deans A, Heierhorst J, Purton L, Izon D, Walkley C
    J Clin Invest, 2014;124(8):3551-65.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression.
    Authors: Wallington-Beddoe C, Powell J, Tong D, Pitson S, Bradstock K, Bendall L
    Cancer Res, 2014;74(10):2803-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.
    Authors: Krutikov K, Zheng Y, Chesney A, Huang X, Vaags A, Evdokimova V, Hough M, Chen E
    PLoS ONE, 2014;9(2):e89649.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. B-cell lymphopoiesis is regulated by cathepsin L.
    Authors: Badano M, Camicia G, Lombardi G, Maglioco A, Cabrera G, Costa H, Meiss R, Piazzon I, Nepomnaschy I
    PLoS ONE, 2013;8(4):e61347.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development.
    Authors: Venigalla, Ram K C, McGuire, Victoria, Clarke, Rosemary, Patterson-Kane, Janet C, Najafov, Ayaz, Toth, Rachel, McCarthy, Pierre C, Simeons, Frederic, Stojanovski, Laste, Arthur, J Simon
    EMBO J, 2013;32(7):1008-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. The inhibitory receptor BTLA controls gammadelta T cell homeostasis and inflammatory responses.
    Authors: Bekiaris V, Sedy J, Macauley M, Rhode-Kurnow A, Ware C
    Immunity, 2013;39(6):1082-94.
  53. Moesin controls clathrin-mediated S1PR1 internalization in T cells.
    Authors: Nomachi, Akira, Yoshinaga, Masanori, Liu, Jaron, Kanchanawong, Pakorn, Tohyama, Kiyoshi, Thumkeo, Dean, Watanabe, Takeshi, Narumiya, Shuh, Hirata, Takako
    PLoS ONE, 2013;8(12):e82590.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
    Authors: Olive V, Sabio E, Bennett M, De Jong C, Biton A, McGann J, Greaney S, Sodir N, Zhou A, Balakrishnan A, Foth M, Luftig M, Goga A, Speed T, Xuan Z, Evan G, Wan Y, Minella A, He L
    Elife, 2013;2(0):e00822.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
    Authors: Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, Chen W, Stepkowski S
    J Immunol, 2013;190(7):3153-62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination.
    Authors: Lee, Baeck-se, Dekker, Joseph D, Lee, Bum-kyu, Iyer, Vishwana, Sleckman, Barry P, Shaffer, Arthur L, Ippolito, Gregory, Tucker, Philip W
    Mol Cell Biol, 2013;33(9):1768-81.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract.
    Authors: Johnson RM, Kerr MS, Slaven JE
    J. Immunol., 2012;188(4):1896-904.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells.
    Authors: Michel M, Pang D, Haque S, Potocnik A, Pennington D, Hayday A
    Proc Natl Acad Sci U S A, 2012;109(43):17549-54.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  60. Apoptotic programs are determined during lineage commitment of CD4+ T effectors: selective regulation of T effector-memory apoptosis by inducible nitric oxide synthase.
    Authors: Purushothaman D, Marcel N, Garg M, Venkataraman R, Sarin A
    J Immunol, 2012;190(1):97-105.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  61. Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration.
    Authors: Gupta S, Marcel N, Talwar S, Garg M, R I, Perumalsamy L, Sarin A, Shivashankar G
    PLoS ONE, 2012;7(9):e43718.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
    Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
    Nature, 2012;491(7426):765-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  63. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
    Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
    J. Immunol., 2011;188(3):1503-13.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010;84(24):12703-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  65. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
    Authors: Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ
    Nat. Med., 2010;16(2):191-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  66. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway.
    Authors: Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ
    J. Immunol., 2009;183(10):6135-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Osteoblastic regulation of B lymphopoiesis is mediated by Gs alpha-dependent signaling pathways.
    Authors: Wu JY, Purton LE, Rodda SJ, Chen M, Weinstein LS, McMahon AP, Scadden DT, Kronenberg HM
    Proc. Natl. Acad. Sci. U.S.A., 2008;105(44):16976-81.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  68. IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development.
    Authors: Vang KB, Yang J, Mahmud SA, Burchill MA, Vegoe AL, Farrar MA
    J. Immunol., 2008;181(5):3285-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
    Authors: Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG
    Blood, 2007;109(9):3706-12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Role of CD30 in B/T segregation in the spleen.
    Authors: Bekiaris V, Withers D, Glanville SH, McConnell FM, Parnell SM, Kim MY, Gaspal FM, Jenkinson E, Sweet C, Anderson G, Lane PJ
    J. Immunol., 2007;179(11):7535-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.
    Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA
    J. Immunol., 2007;178(4):2018-27.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Transforming growth factor-beta1 sensitivity is altered in Abl-Myc- and Raf-Myc-induced mouse pre-B-cell tumors.
    Authors: Letterio J, Rudikoff E, Voong N, Bauer SR
    Stem Cells, 2006;24(12):2611-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Galectin-1 supports survival of naive T cells without promoting cell proliferation.
    Authors: Endharti AT, Zhou YW, Nakashima I, Suzuki H
    Eur. J. Immunol., 2005;35(1):86-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. A recombinant single-chain IL-7/HGFbeta hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S12, CLPs, and pre-pro-B cells.
    Authors: Lai L, Zeff RA, Goldschneider I
    Blood, 2005;107(5):1776-84.
  75. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease.
    Authors: Alpdogan O, Schmaltz C, Muriglan SJ, Kappel BJ, Perales MA, Rotolo JA, Halm JA, Rich BE, van den Brink MR
    Blood, 2001;98(7):2256-65.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

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