Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions (1 - 2).
Recombinant Mouse Mer Fc Chimera Protein, CF
R&D Systems | Catalog # 591-MR
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Key Product Details
- R&D Systems Sf 21 (baculovirus)-derived Recombinant Mouse Mer Fc Chimera Protein (591-MR)
- Quality control testing to verify active proteins with lot specific assays by in-house scientists
- All R&D Systems proteins are covered with a 100% guarantee
Source
Sf 21 (baculovirus)
Accession Number
Structure / Form
Disulfide-linked homodimer
Applications
Binding Activity
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Product Specifications
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived mouse Mer protein
| Mouse Mer (Glu23 - Phe498) Accession # Q60805 |
IEGRMD | Human IgG1 (Pro100 - Lys330) |
| N-terminus | C-terminus |
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
N-terminal Sequence Analysis
Glu23
Predicted Molecular Mass
78.7 kDa (monomer)
SDS-PAGE
110-115 kDa, reducing conditions
Activity
Measured by its binding ability in a functional ELISA.
Immobilized rmMer/Fc Chimera at 10 µg/mL (100 µL/well) can bind rhGas6 with a linear range of 0.03-1 µg/mL.
Immobilized rmMer/Fc Chimera at 10 µg/mL (100 µL/well) can bind rhGas6 with a linear range of 0.03-1 µg/mL.
Reviewed Applications
Read 1 review rated 5 using 591-MR in the following applications:
Formulation, Preparation, and Storage
591-MR
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile PBS.
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| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Calculators
Background: Mer
References
- Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
- Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.
Long Name
Receptor Tyrosine Protein Kinase Mer
Alternate Names
c-Eyk, C-mer, MerTK
Gene Symbol
MERTK
UniProt
Additional Mer Products
Product Documents for Recombinant Mouse Mer Fc Chimera Protein, CF
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Recombinant Mouse Mer Fc Chimera Protein, CF
For research use only
Citations for Recombinant Mouse Mer Fc Chimera Protein, CF
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Application: In vitro bioactivity in cell cultureVerified Customer | Posted 08/30/2017
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