Recombinant Mouse Meteorin-like/METRNL Protein, CF Summary
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CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Meteorin-like protein (METRNL) is a 311 amino acid (aa) protein that shows 45% homology with Meteorin (in mouse). Meteorin itself is a secreted 30 kDa protein that is expressed in glial and neuronal cells and their precursors during development and in the adult (1 ‑ 3). In the adult Meteorin is primarily expressed by astrocytes (3). Meteorin promotes neurite outgrowth, glial cell differentiation, and neuronal survival following excitotoxic injury (2 ‑ 5). It also inhibits sprouting angiogenesis and promotes blood vessel maturation (1). Mouse Meteorin‑like protein is synthesized with a 45 amino acid (aa) signal peptide and is selectively expressed in the otic vesicle during inner ear development (6, 7). Mature mouse Meteorin‑like protein shares 79% and 98% aa sequence identity with human and rat Meteorin‑like protein, respectively. Alternate splicing generates an additional isoform that lacks the N‑terminal 82 amino acids including the signal peptide. R&D Systems in‑house testing indicates that Meteorin‑like protein enhances the outgrowth of neurites from cultured mouse cortical neurons. The promoter region of the METRNL gene contains a recognition site for the Pax2, Pax5, and Pax8 transcription factors, and Pax2 binds specifically to this region (7). METRNL is the only gene found within the terminus of the human chromosome 17 q‑arm which can be deleted in the rare Ring 17 syndrome (8).
- Park, J.A. et al. (2008) Glia 56:247.
- Jorgensen, J.R. et al. (2009) J. Mol. Neurosci. 39:104.
- Lee, H.S. et al. (2010) J. Cell Sci. 123:1959.
- Nishino, J. et al. (2004) EMBO J. 23:1998.
- Jorgensen, J.R. et al. (2011) Neurobiol. Dis. 41:160.
- Accession # Q8VE43.
- Ramialison, M. et al. (2008) Genome Biol. 9:R145.
- Surace, C. et al. (2009) Clin. Genet. 76:256.
Citations for Recombinant Mouse Meteorin-like/METRNL Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Meteorin Is a Novel Therapeutic Target for Wet Age-Related Macular Degeneration
Authors: K Delaunay, A Sellam, V Dinet, A Moulin, M Zhao, E Gelizé, J Canonica, MC Naud, P Crisanti-L, F Behar-Cohe
Journal of Clinical Medicine, 2021;10(13):.
Sample Types: In Vivo
Applications: In Vivo
Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARgamma Signaling.
Authors: Li Z, Song J, Zheng S, Fan M, Guan Y, Qu Y, Xu J, Wang P, Miao C
Sample Types: Whole Cells
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