Recombinant Mouse TINAGL1 Protein, CF

Tubulointerstitial Nephritis Antigen-like (TINAGL1), also known as Lipocalin-7, AZ-1, and Arg1, is an approximately 50 kDa matricellular protein that contains a Somatomedin-B like domain, a vWF-C domain, and a cysteine peptidase domain that lacks the critical active site Cys residue (1, 2). Mouse TINAGL1 shares 90% and 97% aa sequence identity with human and rat TINAGL1, respectively. It is a component of the extracellular matrix in basement membranes (3-5) where it binds to Collagens I and IV, Laminin, Integrins a5 and b1, and the Anastellin fragment of Fibronectin (3-5). TINAGL1 promotes cell adhesion and angiogenic sprouting from vascular endothelial cells (3, 6). It is expressed in the adrenal cortex and medulla, vascular smooth muscle cells, cardiac and skeletal muscle cells, and in blastocysts that are competent for implantation (2, 3, 5, 7).