Recombinant Mouse TINAGL1 (Catalog # 9208-TI) binds to Cultrex Mouse Laminin I in an ELISA Binding Assay. When Cultrex Mouse Laminin I (Catalog # 3400-010-01) is coated at 5 µg/mL, Recombinant Mouse TINAGL1 binds with an ED50 = 1-6 ng/mL.
Antigen-like (TINAGL1), also known as Lipocalin-7, AZ-1, and Arg1, is an
approximately 50 kDa matricellular protein that contains a Somatomedin-B like
domain, a vWF-C domain, and a cysteine peptidase domain that lacks the critical
active site Cys residue (1, 2). Mouse TINAGL1 shares 90% and 97% aa sequence identity
with human and rat TINAGL1, respectively. It is a component of the
extracellular matrix in basement membranes (3-5) where it binds to Collagens I
and IV, Laminin, Integrins a5 and b1, and the Anastellin fragment of Fibronectin (3-5). TINAGL1 promotes
cell adhesion and angiogenic sprouting from vascular endothelial cells (3, 6). It
is expressed in the adrenal cortex and medulla, vascular smooth muscle cells,
cardiac and skeletal muscle cells, and in blastocysts that are competent for
implantation (2, 3, 5, 7).
Kobayashi, M. et al. (2001) J. Steroid Biochem. Mol. Biol. 77:109.
Have you used Recombinant Mouse TINAGL1 Protein, CF?
Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.