Recombinant R. sanguineus Evasin-1 Fc Chimera Protein, CF Summary
(Met-Asp-Pro100 - Lys330)
|IEGR||R. sanguineus Evasin-1|
Accession # P0C8E7.1
Recombinant R.sanguineus Evasin‑1 Fc Chimera (Catalog # 10016-EV) inhibitsRecombinant Human CCL‑3/MIP‑1 alpha -induced chemotaxis of BaF3 mouse pro B cellstransfected with human CCR5. The ED50 for this effect is 0.2‑1.2 μg/mL.
Evasin-1 is a highly selective chemokine-binding protein isolated from tick saliva. The cDNA of tick Evasin-1 encodes a 114 amino acid (aa) precursor, which include a 20 aa signal peptide and the 94 aa mature protein (1). Ticks are blood sucking parasites that secrete a wide variety of immunomodulatory proteins to evade the host immune response. The saliva isolated from Ticks has shown chemokine neutralization activity. A group of proteins contributing to this activity have been identified as chemokine-binding proteins (CHPBs) and named as Evasins (1-3). Evasin-1 shows high affinity binding to a very limited set of three highly homologous CC chemokines: CCL3, CCL4 and CCL18 (1). Since it is a small molecule, Evasin-1 may be therapeutically useful as novel anti-inflammatory agent.
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