Chemical Name: 2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate
Biological ActivityRemdesivir is a viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form, GS 441524 (Cat. No. 7227). Exhibits activity against a range of RNA viruses in vitro (EC50 values are 0.019, 0.07, 0.07 - 0.34, 0.086 - 0.14, and 23.15 μM against RSV, SARS-CoV, MERS-CoV, EBOV and SARS-CoV-2, respectively). Exhibits antiviral efficacy in animal models of MERS-CoV and EBOV infection.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2replication in vitro.
Choy et al.
Antiviral Res., 2020;178:104786
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
Sheahan et al.
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
Warren et al.
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