Potent and selective inhibitor of the TGF-β
type I receptor/ALK5 (IC50
values are 4 and 23 nM for TGF-β
type I receptor autophosphorylation and binding respectively). Selective for TGF-β
type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50
> 16 μ
M). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-γ type I receptor inhibitors.
Gellibert et al.
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.
Li et al.
Cell Stem Cell, 2009;4:16
A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog.
Ichida et al.
Cell Stem Cell, 2009;5:491
The citations listed below are publications that use Tocris products. Selected citations for RepSox include:
Showing Results 1 - 3 of 3