RepSox

Tocris Bioscience | Catalog # 3742

Potent and selective inhibitor of TGF-βRI
Tocris Bioscience

Key Product Details

Description

Potent and selective inhibitor of TGF-βRI

Alternative Names

E-616452,SJN 2511,ALK5 Inhibitor II
View all TGF-beta Receptor Inhibitors »

Product Description

RepSox is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). RepSox is selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming (see our protocols below); also used in protocols to generate CiPSCs from MEFs or β cells from hPSCs (see below); used in protocols to generate pancreatic beta cells from hPSCs or CiPSCs from MEFs. Replaces Sox2 by inducing Nanog expression.

RepSox synthesized to Ancillary Material Grade also available.

For more information about how RepSox may be used, see our protocols: Highly Efficient Generation of CiPSCs from MEFs, Generation of β cells from hPSCs, Reprogramming MEFs into Skeletal Muscle Progenitors.

Product Specifications for RepSox

Molecular Weight

287.32

Formula

C17H13N5

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

CAS Number

446859-33-2

PubChem ID

449054

InChI Key

LBPKYPYHDKKRFS-UHFFFAOYSA-N

SMILES

CC1=NC(C2=NNC=C2C4=NC3=CC=CN=C3C=C4)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.73 100
Ethanol 5.75 20

Preparing Stock Solutions for RepSox

The following data is based on the product molecular weight 287.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.40 mL 34.80 mL
5 mM 0.70 mL 3.48 mL 6.96 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.70 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 33 publications citing the usage of this product.

Product Documents for RepSox

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RepSox

For research use only

Customer Reviews for RepSox (1)

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  • RepSox's ability to alter certain genes
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: skin
    Verified Customer | Posted 06/29/2020
    Mouse primary fibroblasts also treat with RepSox 25 μM.
    Mice received a dose of 1 μmol RepSox or vehicle only topically onto the back skin.
    RepSox 3742

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