RepSox
Chemical Name: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Purity: ≥99%
Biological Activity
RepSox is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). Selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-γ type I receptor inhibitors.
Gellibert et al.
J.Med.Chem., 2004;47:4494 -
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.
Li et al.
Cell Stem Cell, 2009;4:16 -
A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog.
Ichida et al.
Cell Stem Cell, 2009;5:491
Product Datasheets
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Citations for RepSox
The citations listed below are publications that use Tocris products. Selected citations for RepSox include:
6 Citations: Showing 1 - 6
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Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals.
Authors: Yung Et al.
Nat.Commun. 2019;10:4647
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Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Authors: Segal Et al.
Nat Commun 2019;10:3350
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Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.
Authors: Lichtenberger Et al.
Nat Commun 2016;7:10537
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Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
Authors: Mou Et al.
Cell: Stem Cell 2016;19:217
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GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
Authors: Zhou Et al.
J Immunol 2013;190:5057
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Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
Authors: Li Et al.
Am J Physiol Renal Physiol 2013;13:1969
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Mice received a dose of 1 μmol RepSox or vehicle only topically onto the back skin.
