RepSox

Catalog # Availability Size / Price Qty
3742/10
3742/50
RepSox | CAS No. 446859-33-2 | TGF-beta Receptor Inhibitors
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Description: Potent and selective inhibitor of TGF-βRI
Alternative Names: E-616452, SJN 2511, ALK5 Inhibitor II

Chemical Name: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

Purity: ≥99%

Product Details
Citations (5)
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Biological Activity

Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). Selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.

Technical Data

M.Wt:
287.32
Formula:
C17H13N5
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
446859-33-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for RepSox

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