RepSox

  ( 4 citations )    
Product Datasheet
Catalog Number:3742
Alternate Names:E-616452, SJN 2511, ALK5 Inhibitor II
Chemical Name:2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Product Details
Citations (4)
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Reviews
Biological Activity
Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). Selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.
Technical Data
  • M.Wt:
    287.32
  • Formula:
    C17H13N5
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    446859-33-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for RepSox include:

4 Citations: Showing 1 - 4
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  1. Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.
    Authors: Lichtenberger Et al.
    Nat Commun  2016;7:10537
  2. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  3. GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
    Authors: Zhou Et al.
    J Immunol  2013;190:5057
  4. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
    Authors: Li Et al.
    Am J Physiol Renal Physiol  2013;13:1969

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