Chemical Name: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Biological ActivityRepSox is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). Selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.
RepSox synthesized to Ancillary Material Grade also available.
For more information about how RepSox may be used, see our protocols: Highly Efficient Generation of CiPSCs from MEFs, Generation of β cells from hPSCs, Reprogramming MEFs into Skeletal Muscle Progenitors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-γ type I receptor inhibitors.
Gellibert et al.
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.
Li et al.
Cell Stem Cell, 2009;4:16
A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog.
Ichida et al.
Cell Stem Cell, 2009;5:491
Citations for RepSox
The citations listed below are publications that use Tocris products. Selected citations for RepSox include:
6 Citations: Showing 1 - 6
Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals.
Authors: Yung Et al.
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Authors: Segal Et al.
Nat Commun 2019;10:3350
Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.
Authors: Lichtenberger Et al.
Nat Commun 2016;7:10537
Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
Authors: Mou Et al.
Cell: Stem Cell 2016;19:217
GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
Authors: Zhou Et al.
J Immunol 2013;190:5057
Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
Authors: Li Et al.
Am J Physiol Renal Physiol 2013;13:1969
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