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Catalog Number:3742
Alternate Names:E-616452, SJN 2511, ALK5 Inhibitor II
Chemical Name:2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). Selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.
Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). Selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.
Technical Data
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M.Wt:287.32
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Formula:C17H13N5
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Solubility:Soluble to 100 mM in DMSO and to 50 mM in ethanol
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Purity:>99
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Storage:Store at +4°C
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CAS No:446859-33-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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Citations:
The citations listed below are publications that use Tocris products. Selected citations for RepSox include:
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