Catalog Number: 3742
Alternate Names: E-616452, SJN 2511, ALK5 Inhibitor II
Chemical Name: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Biological Activity
Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). Selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-γ type I receptor inhibitors.
    Gellibert et al.
    J.Med.Chem., 2004;47:4494
  2. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.
    Li et al.
    Cell Stem Cell, 2009;4:16
  3. A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog.
    Ichida et al.
    Cell Stem Cell, 2009;5:491

The citations listed below are publications that use Tocris products. Selected citations for RepSox include:

Showing Results 1 - 3 of 3

  1. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell
  2. GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
    Authors: Zhou Et al.
    J Immunol
  3. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
    Authors: Li Et al.
    Am J Physiol Renal Physiol
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