Catalog Number: 2742
Chemical Name: (3β,16β,17α,18β,20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
Biological Activity
Binds the vesicular monoamine transporter (VMAT2) and inhibits transport of biogenic amines into adrenal chromaffin granules and synaptic vesicles. Causes depletion of biogenic amine stores. Antihypertensive and antipsychotic.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Reserpine binding to a vesicular amine transporter expressed in chinese hamster ovary fibroblasts.
    Schuldiner et al.
    J.Biol.Chem., 1993;268:29
  2. Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes.
    Heslop and Curzon
    Neuropharmacology, 1999;38:883
  3. Inhibitory effect of reserpine on dopamine transporter function.
    Metzger et al.
    Eur.J.Pharmacol., 2002;456:39
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