Catalog Number: 2742
Chemical Name: (3β,16β,17α,18β,20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
Biological Activity
Binds the vesicular monoamine transporter (VMAT2) and inhibits transport of biogenic amines into adrenal chromaffin granules and synaptic vesicles. Causes depletion of biogenic amine stores. Antihypertensive and antipsychotic.
Technical Data
  • M.Wt:
    608.68
  • Formula:
    C33H40N2O9
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    50-55-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Reserpine binding to a vesicular amine transporter expressed in chinese hamster ovary fibroblasts.
    Schuldiner et al.
    J.Biol.Chem., 1993;268:29
  2. Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes.
    Heslop and Curzon
    Neuropharmacology, 1999;38:883
  3. Inhibitory effect of reserpine on dopamine transporter function.
    Metzger et al.
    Eur.J.Pharmacol., 2002;456:39
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Reserpine include:

3 Citations: Showing 1 - 3
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  1. Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation.
    Authors: Berrios Et al.
    Neuropsychopharmacology 2016;7:10702
  2. Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
    Authors: Czysz Et al.
    J Immunol 2015;40:766
  3. Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.
    Authors: Prado Et al.
    Cell Tissue Res 2012;188:3062

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