Chemical Name: 1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
Biological ActivityToll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells.
Lee et al.
Imiquimod and resiquimod as novel immunomodulators.
Dockrell and Kinghorn
R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts.
Miyamoto et al.
Modulation of TH1 and Th2 cytokine production with the immune response modifiers, R-848 and imiq.
Wagner et al.
Cell Immunol., 1999;191:10
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Worked well for macrophages and got the desired result by TNF production.