Chemical Name: 1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
Biological ActivityResiquimod is a toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells.
Lee et al.
Imiquimod and resiquimod as novel immunomodulators.
Dockrell and Kinghorn
R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts.
Miyamoto et al.
Modulation of TH1 and Th2 cytokine production with the immune response modifiers, R-848 and imiq.
Wagner et al.
Cell Immunol., 1999;191:10
Citations for Resiquimod
The citations listed below are publications that use Tocris products. Selected citations for Resiquimod include:
2 Citations: Showing 1 - 2
Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine.
Authors: Ming Et al.
Cell Discov 2022;8:10
Imprime PGG Enhances Anti-Tumor Effects of Tumor-Targeting, Anti-Angiogenic, and Immune Checkpoint Inhibitor Antibodies.
Authors: Yumi Et al.
Front Oncol 2022;12:869078
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