Catalog Number: 3672
Biological Activity
Selective NPFF receptor antagonist (Ki values are 58 and 75 nM at hNPFF1 and hNPFF2 receptors respectively). Displays selectivity over several related receptors including NPY Y1 GPR10, GPR54, GPR103 and the opioid receptors. Blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo.
Technical Data
  • M.Wt:
    482.62
  • Formula:
    C26H38N6O3
  • Solubility:
    Soluble to 10 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    876310-60-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice.
    Wang et al.
    Peptides, 2008;29:1183
  2. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia.
    Simonin et al.
    Proc.Natl.Acad.Sci.USA, 2006;103:466
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RF 9 include:

1 Citations: Showing 1 - 1

  1. Novel vasocontractile role of the P2Y14 receptor: characterization of its signalling in porcine isolated pancreatic arteries.
    Authors: Alsaqati Et al.
    Br J Pharmacol 2014;171:701

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