Biological ActivityRF 9 is a selective NPFF receptor antagonist (Ki values are 58 and 75 nM at hNPFF1 and hNPFF2 receptors respectively). Displays selectivity over several related receptors including NPY Y1 GPR10, GPR54, GPR103 and the opioid receptors. Blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice.
Wang et al.
RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia.
Simonin et al.
Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist.
Fang et al.
Citations for RF 9
The citations listed below are publications that use Tocris products. Selected citations for RF 9 include:
2 Citations: Showing 1 - 2
Genetic and neuronal regulation of sleep by neuropeptide VF.
Authors: Lee Et al.
Novel vasocontractile role of the P2Y14 receptor: characterization of its signalling in porcine isolated pancreatic arteries.
Authors: Alsaqati Et al.
Br J Pharmacol 2014;171:701
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