Biological ActivityPotent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats. GnIH homolog.
(Phe-12 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPγS binding.
Gouardères et al.
Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance.
Nichols et al.
New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
Hinuma et al.
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VersaClone cDNA Plasmids
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