RFRP-1 (human)
Tocris Bioscience | Catalog # 5677
Potent NPFF receptor agonist
Discontinued Product
5677 has been discontinued.
View all Neuropeptide FF/AF Receptor Agonists products.
Key Product Details
Description
Potent NPFF receptor agonist
Product Description
RFRP-1 (human) is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats. GnIH homolog.
Product Specifications for RFRP-1 (human)
Molecular Weight
1428.72
Formula
C67H101N19O14S
Storage
Store at -20°C
CAS Number
311309-25-8
PubChem ID
71462794
InChI Key
STXUPUZSJMRDJT-IWPKOFGPSA-N
SMILES
[H]N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Calculators
Background References
References are publications that support the biological activity of the product.
- Nichols Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. Peptides 2010 PMID: 20797420
- Hinuma New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell.Biol. 2000 PMID: 11025660
- Gouardères Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPγS binding. Neuropharmacology 2006 PMID: 17011599
Product Documents for RFRP-1 (human)
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for RFRP-1 (human)
For research use only
Related Research Areas
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