Rhein

Catalog # Availability Size / Price Qty
6867/10
6867/50
Rhein | CAS No. 478-43-3 | Other Oxidase/Oxygenase Compounds
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Description: FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3

Chemical Name: 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid

Purity: ≥98%

Product Details
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Biological Activity

FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 μM; Ki = 1.8 μM). Competitively binds enzyme at active site preventing binding of N6-methyladenosine (m6A) substrate and resulting in accumulation of DNA damage in cells. Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 μM, respectively). Sensitizes glioblastoma cells to alkylating agents. Active in vivo.

Technical Data

M.Wt:
284.22
Formula:
C15H8O6
Solubility:
Soluble to 100 mM in 1.1eq. NaOH
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
478-43-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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