Rhein
Chemical Name: 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
Purity: ≥98%
Biological Activity
Rhein is a FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 μM; Ki = 1.8 μM). Competitively binds enzyme at active site preventing binding of N6-methyladenosine (m6A) substrate and resulting in accumulation of DNA damage in cells. Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 μM, respectively). Sensitizes glioblastoma cells to alkylating agents. Active in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Fluorescent RNA Aptamers as a Tool to Study RNA-Modifying Enzymes.
Svensen and Jaffrey
Cell Chem.Biol., 2016;23:415 -
Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor.
Chen et al.
J.Am.Chem.Soc., 2012;134:17963 -
Rhein inhibits AlkB repair enzymes and sensitizes cells to methylated DNA damage.
Li et al.
J.Biol.Chem., 2016;291:11083
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Rhein
There are currently no reviews for this product. Be the first to review Rhein and earn rewards!
Have you used Rhein?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
