Rhosin hydrochloride

Catalog # Availability Size / Price Qty
5003/10
5003/50

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Rhosin hydrochloride | CAS No. 1281870-42-5 | Rho GTPase Inhibitors
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Description: Rho inhibitor

Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Rhosin hydrochloride is a Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.

Technical Data

M.Wt:
394.86
Formula:
C20H18N6O.HCl
Solubility:
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1281870-42-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Rhosin hydrochloride

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