Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
Biological ActivityRhosin hydrochloride is a Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.
Shang et al.
Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases.
Shang et al.
Citation for Rhosin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Rhosin hydrochloride include:
1 Citation: Showing 1 - 1
Gadolinium-based contrast agent accelerates the migration of astrocyte via integrin αvβ3 signaling pathway
Authors: Ariyani Et al.
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