Rhosin hydrochloride

   
Product Datasheet
Catalog Number:5003
Chemical Name:D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
Product Details
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Biological Activity
Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.
Technical Data
  • M.Wt:
    394.86
  • Formula:
    C20H18N6O.HCl
  • Solubility:
    Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    1281870-42-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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