RHPS 4 methosulfate
Chemical Name: 3,11-Difluoro-6,8,13-trimethylquino[4,3,2-kl]acridinium methylsulfate
Biological ActivityTelomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice. Sensitizes radiation resistant glioblastoma cell lines to radiation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.
Phatak et al.
RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.
Lagah et al.
PLoS One, 2014;9:e86187
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
Salvati et al.
The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells.
Berardinelli et al.
DNA Repair (Amst.), 2015;25:104
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