Catalog Number: 5311
Chemical Name: 3,11-Difluoro-6,8,13-trimethylquino[4,3,2-kl]acridinium methylsulfate
Biological Activity
Telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water with gentle warming and to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.
    Lagah et al.
    PLoS One, 2014;9:e86187
  2. Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
    Salvati et al.
    J.Clin.Invest., 2007;117:3236
  3. Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.
    Phatak et al.
    Br.J.Cancer, 2007;96:1223
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