Telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro
. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice.
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RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.
Lagah et al.
PLoS One, 2014;9:e86187
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
Salvati et al.
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.
Phatak et al.