RHPS 4 methosulfate

Key Product Details

Product Description

RHPS 4 methosulfate is a telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice. Sensitizes radiation resistant glioblastoma cell lines to radiation.

Product Specifications for RHPS 4 methosulfate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RHPS 4 methosulfate

The following data is based on the product molecular weight 458.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.91 mL	54.53 mL	109.06 mL
1 mM	2.18 mL	10.91 mL	21.81 mL
2 mM	1.09 mL	5.45 mL	10.91 mL
10 mM	0.22 mL	1.09 mL	2.18 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Berardinelli The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells. DNA Repair (Amst.) 2015 PMID: 25467559
• Salvati Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J.Clin.Invest. 2007 PMID: 17932567
• Phatak Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br.J.Cancer 2007 PMID: 17406367
• Lagah RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS One 2014 PMID: 24454961

Product Documents for RHPS 4 methosulfate