Rilpivirine

Key Product Details

Product Description

Rilpivirine is a potent diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It has high antiviral activity against wild-type HIV-1 and mutant viruses (EC₅₀ values are 0.4 and 0.1-2.0 nM, respectively in a cell-based assay). This compound is orally bioavailable.

Product Specifications for Rilpivirine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Rilpivirine

The following data is based on the product molecular weight 366.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.46 mL	27.29 mL	54.58 mL
2.5 mM	1.09 mL	5.46 mL	10.92 mL
5 mM	0.55 mL	2.73 mL	5.46 mL
25 mM	0.11 mL	0.55 mL	1.09 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Baert Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment. Eur.J.Pharm.Biopharm. 2009 PMID: 19328850
• Janssen In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (R278474, rilpivirine) J.Med.Chem. 2005 PMID: 15771434

Product Documents for Rilpivirine