Catalog Number: 0768
Chemical Name: 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
Biological Activity
Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.
Technical Data
  • M.Wt:
    270.66
  • Formula:
    C8H5F3N2OS.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    850608-87-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.
    Fumagalli et al.
    Eur.J.Pharmacol., 2008;578:171
  2. Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones.
    Umeniya and Berger
    Br.J.Pharmacol., 1995;116:3227
  3. Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.
    Song et al.
    J.Pharmacol.Exp.Ther., 1997;282:707
  4. Na+ channels as targets for neuroprotective drugs.
    Taylor and Meldrum
    TiPS, 1995;16:309
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Riluzole hydrochloride include:

9 Citations: Showing 1 - 9
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  1. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression.
    Authors: Rosenberg Et al.
    Front Neural Circuits 2015;8:42614
  2. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.
    Authors: Du Et al.
    Nat Commun 2015;6:6626
  3. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.
    Authors: Du Et al.
    Nat.Commun. 2015;6:6626
  4. Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
    Authors: Veettil Et al.
    PLoS Pathog 2014;10:e1004389
  5. β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro.
    Authors: Viemari Et al.
    Neurochem Int 2013;7:179
  6. Riluzole elevates GLT-1 activity and levels in striatal astrocytes.
    Authors: Carbone Et al.
    BMC Neurosci 2012;60:42613
  7. Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation.
    Authors: Carbone Et al.
    Cells 2012;13:38
  8. Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse.
    Authors: Morgado-Valle Et al.
    J Neurosci 2010;30:3634
  9. The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells.
    Authors: Le Et al.
    J Invest Dermatol 2010;130:2240

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