Catalog Number: 0768
Chemical Name: 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
Biological Activity
Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.
    Fumagalli et al.
    Eur.J.Pharmacol., 2008;578:171
  2. Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones.
    Umeniya and Berger
    Br.J.Pharmacol., 1995;116:3227
  3. Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.
    Song et al.
    J.Pharmacol.Exp.Ther., 1997;282:707
  4. Na+ channels as targets for neuroprotective drugs.
    Taylor and Meldrum
    TiPS, 1995;16:309
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