Riluzole hydrochloride

Catalog # Availability Size / Price Qty
Riluzole hydrochloride | CAS No. 850608-87-6 | Glutamate Receptor Inhibitors
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Description: GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels

Chemical Name: 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride

Purity: ≥98%

Product Details
Citations (15)

Biological Activity

Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes. Also activates TRPC5 channels. Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic, anesthetic and neuroprotective properties.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma.
    Abushahba W, Olabisi O, Jeong B, Boregowda R, Wen Y, Liu F, Goydos J, Lasfar A, Cohen-Solal K
    PLoS ONE, 2012;7(10):e47312.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. Na+ channels as targets for neuroprotective drugs.
    Taylor and Meldrum
    TiPS, 1995;16:309
  4. Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.
    Fumagalli et al.
    Eur.J.Pharmacol., 2008;578:171
  5. Riluzole activates TRPC5 channels independently of PLC activity.
    Richter et al.
    Br.J.Pharmacol., 2014;171:158
  6. Differential action of Riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.
    Song et al.
    J.Pharmacol.Exp.Ther., 1997;282:707
  7. Inhibition by Riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones.
    Umeniya and Berger
    Br.J.Pharmacol., 1995;116:3227

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Citations for Riluzole hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Riluzole hydrochloride include:

15 Citations: Showing 1 - 10

  1. Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
    Authors: Zhang Et al.
    Neuron  2018;98:918
  2. Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer.
    Authors: Sexton Et al.
    Sci Rep  2018;8:16008
  3. Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo.
    Authors: Shin Et al.
    Oncogenesis  2018;7:86
  4. Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells.
    Authors: Sperling Et al.
    Oncotarget  2017;8:96697
  5. R.zole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells.
    Authors: Dolfi Et al.
    Oncotarget  2017;8:44639
  6. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression.
    Authors: Rosenberg Et al.
    Front Neural Circuits  2015;8:42614
  7. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.
    Authors: Du Et al.
    Nat Commun  2015;6:6626
  8. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.
    Authors: Du Et al.
    Nat.Commun.  2015;6:6626
  9. Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
    Authors: Veettil Et al.
    PLoS Pathog  2014;10:e1004389
  10. β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro.
    Authors: Viemari Et al.
    Neurochem Int  2013;7:179


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