Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+
-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+
channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.
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All Tocris products are intended for laboratory research use only.
Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.
Fumagalli et al.
Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones.
Umeniya and Berger
Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.
Song et al.
Na+ channels as targets for neuroprotective drugs.
Taylor and Meldrum
The citations listed below are publications that use Tocris products. Selected citations for Riluzole hydrochloride include:
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