Antagonist at σ
values are 1480 and 386 nM at σ1
receptors respectively). Also binds to the dopamine transporter (IC50
= 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo
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All Tocris products are intended for laboratory research use only.
Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain.
Ferris et al.
Life Sci., 1986;38:2329
Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the dopamine transporter.
Husbands et al.
Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters.
Matsumoto et al.