Chemical Name: 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)propyl]-9H-carbazole dihydrochloride
Biological ActivityRimcazole dihydrochloride is an antagonist at σ receptors (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively). Also binds to the dopamine transporter (IC50 = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain.
Ferris et al.
Life Sci., 1986;38:2329
Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the DA transporter.
Husbands et al.
Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than DA transporters.
Matsumoto et al.
Citation for Rimcazole dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Rimcazole dihydrochloride include:
1 Citation: Showing 1 - 1
σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
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