Rimcazole dihydrochloride

Key Product Details

Product Description

Rimcazole dihydrochloride is an antagonist at σ receptors (IC₅₀ values are 1480 and 386 nM at σ₁ and σ₂ receptors respectively). Also binds to the dopamine transporter (IC₅₀ = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo.

Product Specifications for Rimcazole dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Rimcazole dihydrochloride

The following data is based on the product molecular weight 394.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.36 mL	126.78 mL	253.56 mL
0.5 mM	5.07 mL	25.36 mL	50.71 mL
1 mM	2.54 mL	12.68 mL	25.36 mL
5 mM	0.51 mL	2.54 mL	5.07 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Husbands Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the DA transporter. J.Med.Chem. 1997 PMID: 9435903
• Matsumoto Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than DA transporters. Neuropharmacology 2001 PMID: 11684152
• Ferris Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life Sci. 1986 PMID: 2873494

Product Documents for Rimcazole dihydrochloride