RIPA 56

Key Product Details

Product Description

RIPA 56 is a potent and metabolically stable receptor-interacting protein kinase 1 (RIPK1) inhibitor (EC₅₀ = 13 nM). RIPA-56 shows no inhibition of RIP3 kinase at 10 μM. RIPA 56 blocks necroptosis and aging of the mouse male reproductive system. RIPA 56 reduces tumor necrosis factor α (TNFα)-induced mortality and multi-organ damage in a mouse model of systemic inflammatory response syndrome (SIRS). RIPA 56 is orally bioavailable.

Product Specifications for RIPA 56

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RIPA 56

The following data is based on the product molecular weight 221.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.52 mL	22.59 mL	45.19 mL
5 mM	0.90 mL	4.52 mL	9.04 mL
10 mM	0.45 mL	2.26 mL	4.52 mL
50 mM	0.09 mL	0.45 mL	0.90 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ren Discovery of a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) for the treatment of systemic inflammatory response syndrome. J.Med.Chem. 2017 PMID: 27992216
• Zhuang Small-molecule inhibitors of necroptosis: current status and perspectives. J.Med.Chem. 2019 PMID: 31622096
• Li RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. Elife 2017 PMID: 28807105

Product Documents for RIPA 56