Chemical Name: N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide
Biological ActivityRIPA 56 is a potent and metabolically stable receptor-interacting protein kinase 1 (RIPK1) inhibitor (EC50 = 13 nM). RIPA-56 shows no inhibition of RIP3 kinase at 10 μM. RIPA 56 blocks necroptosis and aging of the mouse male reproductive system. RIPA 56 reduces tumor necrosis factor α (TNFα)-induced mortality and multi-organ damage in a mouse model of systemic inflammatory response syndrome (SIRS). RIPA 56 is orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for RIPA 56
There are currently no reviews for this product. Be the first to review RIPA 56 and earn rewards!
Have you used RIPA 56?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image