Chemical Name: 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine
Biological ActivitySelective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and characterization of novel TRPV4 modulators.
Vincent et al.
Citations for RN 1747
The citations listed below are publications that use Tocris products. Selected citations for RN 1747 include:
3 Citations: Showing 1 - 3
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
Authors: Shi Et al.
Am J Physiol Renal Physiol 2015;21:4852
TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats.
Authors: Vizin Et al.
Acta Physiol 2015;214:275
Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
Authors: Shabir Et al.
World J Gastroenterol 2013;305:F396
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