Catalog Number: 3745
Chemical Name: 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine
Biological Activity
Selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).
Technical Data
  • M.Wt:
    395.87
  • Formula:
    C17H18ClN3O4S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    1024448-59-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and characterization of novel TRPV4 modulators.
    Vincent et al.
    Biochem.Biophys.Res.Comms., 2009;389:490
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RN 1747 include:

2 Citations: Showing 1 - 2
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  1. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
    Authors: Shi Et al.
    Am J Physiol Renal Physiol 2015;21:4852
  2. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    World J Gastroenterol 2013;305:F396

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