Selective TRPV4 agonist (EC50
values are 0.77, 4.0 and 4.1 μ
M for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50
values are 0.77, >30, >30 and >100 μ
M for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50
= 4 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification and characterization of novel TRPV4 modulators.
Vincent et al.
The citations listed below are publications that use Tocris products. Selected citations for RN 1747 include:
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