RN 1747

Catalog # Availability Size / Price Qty
3745/10
3745/50
RN 1747 | CAS No. 1024448-59-6 | TRPV Agonists
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Description: Selective TRPV4 agonist

Chemical Name: 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

Selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).

Technical Data

M.Wt:
395.87
Formula:
C17H18ClN3O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1024448-59-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification and characterization of novel TRPV4 modulators.
    Vincent et al.
    Biochem.Biophys.Res.Comms., 2009;389:490

Product Datasheets

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Citations for RN 1747

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3 Citations: Showing 1 - 3

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