Ro 0437626 (CAS 134362-79-1): R&D Systems
Catalog Number: 2188
Chemical Name: N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide
Biological Activity
Selective P2X1 purinergic receptor antagonist (IC50 = 3 μM) that displays > 30-fold selectivity over P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).
Technical Data
  • M.Wt:
    525.66
  • Formula:
    C27H35N5O4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    134362-79-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats.
    King et al.
    Br.J.Pharmacol., 2004;142:519
  2. Purinoceptors as therapeutic targets for lower urinary tract dysfunction.
    Ford et al.
    Br.J.Pharmacol., 2006;147:S132
  3. Discovery and synthesis of a novel and selective drug-like P2X1 antagonist.
    Jaime-Figueroa et al.
    Bioorg.Med.Chem.Lett., 2005;15:3292

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