Ro 0437626

Key Product Details

Product Description

Ro 0437626 is a selective P2X₁ purinergic receptor antagonist (IC₅₀ = 3 μM) that displays > 30-fold selectivity over P2X₂, P2X₃ and P2X_2/3 receptors (IC₅₀ > 100 μM).

Product Specifications for Ro 0437626

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ro 0437626

The following data is based on the product molecular weight 525.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.90 mL	9.51 mL	19.02 mL
5 mM	0.38 mL	1.90 mL	3.80 mL
10 mM	0.19 mL	0.95 mL	1.90 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• King Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br.J.Pharmacol. 2004 PMID: 15148261
• Ford Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 2006 PMID: 16465177
• Jaime-Figueroa Discovery and synthesis of a novel and selective drug-like P2X₁ antagonist. Bioorg.Med.Chem.Lett. 2005 PMID: 15927468

Product Documents for Ro 0437626