Ro 10-5824 dihydrochloride
Chemical Name: 5-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-4-pyrimidinamine dihydrochloride
Biological ActivityRo 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM). Displays 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
RO-10-5824 is a selective DA D4 receptor agonist that increases novel object exploration in C57 mice.
Powell et al.
Citation for Ro 10-5824 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Ro 10-5824 dihydrochloride include:
1 Citation: Showing 1 - 1
Bidirectional modulation of hippocampal synaptic plasticity by Dopaminergic D4-receptors in the CA1 area of hippocampus.
Authors: Navakkode Et al.
Sci Rep 2017;7:15571
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