Catalog Number: 2329
Chemical Name: 5-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-4-pyrimidinamine dihydrochloride
Biological Activity
Selective dopamine D4 receptor partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM). Displays 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.
Technical Data
  • M.Wt:
    353.29
  • Formula:
    C17H20N4.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    189744-94-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice.
    Powell et al.
    Neuropharmacology, 2003;44:473

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