Selective dopamine D4
receptor partial agonist (EC50
= 205 nM) that binds with high affinity (Ki
= 5.2 nM). Displays 250-fold selectivity over D3
receptors and > 1000-fold selectivity over D2
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RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice.
Powell et al.