Ro 25-6981 maleate

  ( 28 citations )    
Product Datasheet
Catalog Number:1594
Chemical Name:(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
Product Details
Citations (28)
Supplemental Products
Reviews
Biological Activity
Potent and selective activity-dependent blocker of NMDA receptors containing the GluN2B (formally NR2B) subunit. IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations GluN1C/GluN2B and GluN1C/GluN2A respectively. Displays neuroprotectant effects in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data
  • M.Wt:
    455.55
  • Formula:
    C22H29NO2.C4H4O4
  • Solubility:
    Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    1312991-76-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ro 25-6981 maleate include:

28 Citations: Showing 1 - 10
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  1. Adenylyl Cyclase 1 Is Required for Ethanol-Induced Locomotor Sensitization and Associated Increases in NMDA Receptor Phosphorylation and Function in the Dorsal Medial Striatum.
    Authors: Bosse Et al.
    J Pharmacol Exp Ther  2017;363:148
  2. Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.
    Authors: France
    Neuropharmacology  2017;112:76
  3. β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.
    Authors: Chen Et al.
    Nature Communications  2016;7:12531
  4. NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline.
    Authors: McQuail Et al.
    J Neurosci  2016;36:12537
  5. MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit.
    Authors: Volkmann Et al.
    PLoS One  2016;11:e0148129
  6. Osmotic Edema Rapidly Increases Neuronal Excitability Through Activation of NMDA Receptor-Dependent Slow Inward Currents in Juvenile and Adult Hippocampus.
    Authors: Lauderdale Et al.
    ASN Neuro  2015;7
  7. ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization.
    Authors: Tindi Et al.
    J Neurosci  2015;35:8986
  8. A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.
    Authors: Smith Et al.
    Mol Pharmacol  2014;86:390
  9. The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression.
    Authors: Jim&eacutenez-Sánchez Et al.
    Neuropsychopharmacology  2014;39:2673
  10. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
    Authors: Koeglsperger Et al.
    Glia  2013;61:985
  11. Knockdown of BNST GluN2B-containing NMDA receptors mimics the actions of ketamine on novelty-induced hypophagia.
    Authors: Louderback Et al.
    Psychoneuroendocrinology  2013;3:e331
  12. Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase.
    Authors: Trepanier Et al.
    Sci Rep  2013;3:926
  13. Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors.
    Authors: Hamida Et al.
    Transl Psychiatry  2013;33:14369
  14. Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
    Authors: Liu Et al.
    J Neurophysiol  2013;110:505
  15. Treatment with a clinically-relevant dose of methylphenidate alters NMDA receptor composition and synaptic plasticity in the juvenile rat prefrontal cortex.
    Authors: Urban Et al.
    Mol Brain  2013;101:65
  16. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of σ-1 and IP3 receptors.
    Authors: Ishima and Hashimoto
    Neurobiol Learn Mem  2012;7:e37989
  17. β-Estradiol unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus.
    Authors: Nebieridze Et al.
    PLoS One  2012;37:1845
  18. NMDARs mediate the role of monoamine oxidase A in pathological aggression.
    Authors: Bortolato Et al.
    J Neurosci  2012;32:8574
  19. Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex.
    Authors: Hoshiko Et al.
    J Neurosci  2012;32:15106
  20. NMDA receptors and BAX are essential for Aβ impairment of LTP.
    Authors: Olsen and Sheng
    Sci Rep  2012;2:225
  21. Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses.
    Authors: Xie Et al.
    J Neurosci  2011;4:44
  22. Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice.
    Authors: Noel Et al.
    Proc Natl Acad Sci U S A  2011;108:5069
  23. Activation of NR2A receptors induces ischemic tolerance through CREB signaling.
    Authors: Terasaki Et al.
    J Cereb Blood Flow Metab  2010;30:1441
  24. NMDA receptor-mediated long-term alterations in epileptiform activity in experimental chronic epilepsy.
    Authors: Hellier Et al.
    Neuropharmacology  2009;56:414
  25. Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons.
    Authors: Beazely Et al.
    J Biol Chem  2009;284:8054
  26. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.
    Authors: Niswender Et al.
    Mol Pharmacol  2008;74:1345
  27. Cerebellar granule cells cultured from adolescent rats express functional NMDA receptors: an in vitro model for studying the developing cerebellum.
    Authors: Popp Et al.
    J Neurochem  2008;106:900
  28. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.
    Authors: Ge Et al.
    Neuron  2007;54:559
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Human GRIN2B/NMDAR2B (NP_000825) VersaClone cDNA

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