Ro 25-6981 maleate

Tocris Bioscience | Catalog # 1594

GluN2B-selective NMDA antagonist
Tocris Bioscience

Key Product Details

Description

GluN2B-selective NMDA antagonist
View all NMDA Receptor Antagonists »

Product Description

Ro 25-6981 maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the GluN2B (formally NR2B) subunit. IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations GluN1C/GluN2B and GluN1C/GluN2A respectively. Displays neuroprotectant effects in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for Ro 25-6981 maleate

Molecular Weight

455.55

Formula

C22H29NO2.C4H4O4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate

CAS Number

1312991-76-6

PubChem ID

53250677

InChI Key

FYJZEHCQSUBZDY-SEELMCCHSA-N

SMILES

OC(=O)\C=C/C(O)=O.C[C@@H](CN1CCC(CC2=CC=CC=C2)CC1)[C@@H](O)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.56 10 with gentle warming
DMSO 45.55 100

Preparing Stock Solutions for Ro 25-6981 maleate

The following data is based on the product molecular weight 455.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.20 mL 10.98 mL 21.95 mL
5 mM 0.44 mL 2.20 mL 4.39 mL
10 mM 0.22 mL 1.10 mL 2.20 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 37 publications citing the usage of this product.

Product Documents for Ro 25-6981 maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ro 25-6981 maleate

For research use only

Citations for Ro 25-6981 maleate

Customer Reviews for Ro 25-6981 maleate (1)

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  • Effect of Ro 25-6981 maleate on NMDA-receptor mediated current in the basolateral amygdala following chronic ethanol exposure
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Basolateral Amygdala Slices
    Verified Customer | Posted 05/10/2019
    We used this drug to block NMDA receptors containing the GluN2B subunit on pyramidal neurons in the basolateral amygdala (BLA). We recorded from coronal sections of BLA and bath applied Ro 25-6981 maleate for 10 minutes.
    Ro 25-6981 maleate 1594

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