Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50
values are 0.009 and 52 μ
M for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo
and in vitro
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All Tocris products are intended for laboratory research use only.
Ro 25-6981, a highly potent and selective blocker of N-Methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.
Fischer et al.
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (ε2) subunit.
Lynch et al.
The NR2B- selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(±)-(R*,S*)-α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamin
Kosowski and Liljequist
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