Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50
= 3 μ
M for inhibition of IL-2 interaction with IL-2R α
-subunit). Appears to compete with IL-2Rα
for its binding site on IL-2.
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All Tocris products are intended for laboratory research use only.
Discovery of a potent small molecule IL-2 inhibitor through fragment assembly.
Braisted et al.
Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2.
Tilley et al.