Ro 26-4550 trifluoroacetate
Chemical Name: N-[[(3R)-1-(Aminoiminomethyl)-3-piperidinyl]acetyl]-4-(phenylethynyl)-L-phenylalanine methyl ester trifluoroacetate
Biological ActivityCompetitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of a potent small molecule IL-2 inhibitor through fragment assembly.
Braisted et al.
Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2.
Tilley et al.
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