Ro 26-4550 trifluoroacetate

Catalog # Availability Size / Price Qty
1794/10
Ro 26-4550 trifluoroacetate | CAS No. 1217448-66-2 | Additional Cytokine Receptor Products
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Description: Competitive inhibitor of IL-2/ IL-2Rα receptor interaction

Chemical Name: N-[[(3R)-1-(Aminoiminomethyl)-3-piperidinyl]acetyl]-4-(phenylethynyl)-L-phenylalanine methyl ester trifluoroacetate

Purity: ≥98%

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Biological Activity

Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.

Technical Data

M.Wt:
560.57
Formula:
C26H30N4O3.CF3CO2H
Solubility:
Soluble to 50 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
1217448-66-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of a potent small molecule IL-2 inhibitor through fragment assembly.
    Braisted et al.
    J.Am.Chem.Soc., 2003;125:3714
  2. Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2.
    Tilley et al.
    J.Am.Chem.Soc., 1997;119:7589

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