Ro 31-8220 mesylate

Catalog # Availability Size / Price Qty
2002/10
Ro 31-8220 mesylate | CAS No. 138489-18-6 | Broad Spectrum Protein Kinase Inhibitors
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Description: Protein kinase inhibitor
Alternative Names: Bisindolylmaleimide IX

Chemical Name: 3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate

Purity: ≥97%

Product Details
Citations (6)
Reviews

Biological Activity

Protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range.

Technical Data

M.Wt:
553.65
Formula:
C25H23N5O2S.CH3SO3H
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥97%
Storage:
Desiccate at -20°C
CAS No:
138489-18-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent, selective inhibitors of protein kinase C.
    Davis et al.
    FEBS Lett., 1989;259:61
  2. Inhibition of voltage-dependent sodium channels by Ro 31-8220, a 'specific' protein kinase C inhibitor.
    Lingameneni et al.
    FEBS Lett., 2000;473:265
  3. Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    Davies et al.
    Biochem.J., 2000;351:95
  4. RO 31-8220 activates c-Jun N-terminal kinase and glycogen synthase in rat adipocytes and L6 myotubes. Comparison to actions of Ins.
    Standaert et al.
    Endocrinology, 1999;150:2145

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Citations for Ro 31-8220 mesylate

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