Ro 48-8071 fumarate

Tocris Bioscience | Catalog # 5389

2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
Tocris Bioscience

Key Product Details

Description

2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
View all Other Lipid Metabolism Inhibitors »

Product Description

Ro 48-8071 fumarate is a 2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).

Product Specifications for Ro 48-8071 fumarate

Molecular Weight

564.44

Formula

C23H27BrFNO2.C4H4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone

CAS Number

189197-69-1

PubChem ID

9959583

InChI Key

XCYAYLWZCRGKDS-WLHGVMLRSA-N

SMILES

FC1=C(C(C2=CC=C(Br)C=C2)=O)C=CC(OCCCCCCN(C)CC=C)=C1.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.29 20 with gentle warming
DMSO 56.44 100

Preparing Stock Solutions for Ro 48-8071 fumarate

The following data is based on the product molecular weight 564.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.86 mL 17.72 mL
5 mM 0.35 mL 1.77 mL 3.54 mL
10 mM 0.18 mL 0.89 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Ro 48-8071 fumarate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ro 48-8071 fumarate

For research use only

Citations for Ro 48-8071 fumarate

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