Catalog Number: 5389
Chemical Name: (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone
Biological Activity
2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.
    Morand et al.
    J.Lipid.Res., 1997;38:373
  2. An inverse docking approach for identifying new potential anti-cancer targets.
    Grinter et al.
    J.Mol.Graph Model., 2011;29:795
  3. Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection.
    Shoemaker et al.
    PLoS One., 2013;8:e56265
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