2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50
= 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50
= 1.74 μ
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All Tocris products are intended for laboratory research use only.
Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.
Morand et al.
An inverse docking approach for identifying new potential anti-cancer targets.
Grinter et al.
J.Mol.Graph Model., 2011;29:795
Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection.
Shoemaker et al.
PLoS One., 2013;8:e56265