Ro 48-8071 fumarate

Catalog # Availability Size / Price Qty
5389/50
5389/10

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Ro 48-8071 fumarate | CAS No. 189197-69-1 | Additional Isomerase Inhibitors
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Description: 2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis

Chemical Name: (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone

Purity: ≥99%

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Biological Activity

Ro 48-8071 fumarate is a 2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).

Technical Data

M.Wt:
564.44
Formula:
C23H27BrFNO2.C4H4O4
Solubility:
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
189197-69-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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