RO 5263397 hydrochloride

Key Product Details

Product Description

RO 5263397 hydrochloride is a potent trace amine 1 (TA₁) receptor agonist (EC₅₀ values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice.

Product Specifications for RO 5263397 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RO 5263397 hydrochloride

The following data is based on the product molecular weight 230.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.34 mL	21.68 mL	43.35 mL
5 mM	0.87 mL	4.34 mL	8.67 mL
10 mM	0.43 mL	2.17 mL	4.34 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Galley Discovery and characterization of 2-aminooxazolines as highly potent, selective, and orally active TAAR1 agonists. ACS.Med.Chem.Letts. 2015 PMID: 26985297
• Schwartz Trace amine-associated receptor 1 regulates wakefulness and EEG spectral composition. Neuropsychopharmacology. 2017 PMID: 27658486
• Espinoza Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397. Front.Pharmacol. 2018 PMID: 29977204

Product Documents for RO 5263397 hydrochloride