RO 5263397 hydrochloride
Chemical Name: (4S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydro-2-oxazolamine hydrochloride
Biological ActivityPotent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397.
Espinoza et al.
Discovery and characterization of 2-aminooxazolines as highly potent, selective, and orally active TAAR1 agonists.
Galley et al.
Trace amine-associated receptor 1 regulates wakefulness and EEG spectral composition.
Schwartz et al.
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