RO 5263397 hydrochloride

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RO 5263397 hydrochloride | Trace Amine 1 (TA1) Receptor Agonists
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Description: Potent TA1 receptor agonist

Chemical Name: (4S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydro-2-oxazolamine hydrochloride

Purity: ≥98%

Product Details

Biological Activity

RO 5263397 hydrochloride is a potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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