Ro 60-0175 fumarate

Catalog # Availability Size / Price Qty
Ro 60-0175 fumarate | CAS No. 169675-09-6 | 5-HT2C Receptor Agonists
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Description: Potent, selective 5-HT2C agonist

Chemical Name: (αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate

Purity: ≥98%

Product Details
Citations (10)
Supplemental Products

Biological Activity

Ro 60-0175 fumarate is a potent, selective 5-HT2 receptor agonist; shows selectivity for the 5-HT2C subtype (pKi values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo.

Technical Data

Soluble to 5 mM in water and to 20 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Ro 60-0175 fumarate

The citations listed below are publications that use Tocris products. Selected citations for Ro 60-0175 fumarate include:

10 Citations: Showing 1 - 10

  1. Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
    Authors: Nagata Et al.
    Sci Rep  2019;9:16438
  2. Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens.
    Authors: Kasper Et al.
    J Neurophysiol  2015;69:78
  3. 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence.
    Authors: Martin Et al.
    Synapse  2015;18
  4. Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress.
    Authors: Martin Et al.
    J Neurochem  2014;131:566
  5. Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization.
    Authors: Craige and Unterwald
    Behav Brain Res  2013;238:206
  6. Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys.
    Authors: Manvich Et al.
    J Pharmacol Exp Ther  2012;341:424
  7. Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis.
    Authors: Yu and Yamaguchi
    J Biol Chem  2010;103:648
  8. 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations.
    Authors: Yu and Yamaguchi
    J Neurophysiol  2009;102:752
  9. Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass.
    Authors: Kawahara Et al.
    J Neurosci  2008;28:12834
  10. Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.
    Authors: Mbaki
    Br J Pharmacol  2008;155:343


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