Catalog Number: 2913
Chemical Name: (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
Biological Activity
Selective, non-competitive mGlu2 antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of heterocyclic enol ethers and their use as a group 2 metabotropic glutamate receptor antagonists.
    Kolczewski et al.
    Bioorg.Med.Chem.Lett., 1999;9:2173
  2. Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
    Brauner-Osbourne et al.
    Curr.Drug Targets., 2007;8:169

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