Chemical Name: (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
Biological ActivitySelective, non-competitive mGlu2 antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis of heterocyclic enol ethers and their use as a group 2 metabotropic glutamate receptor antagonists.
Kolczewski et al.
Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
Brauner-Osbourne et al.
Curr.Drug Targets., 2007;8:169
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