Selective, non-competitive mGlu2
antagonist. Inhibits GTPγ35
S binding to mGlu2
-containing membranes (IC50
= 0.11 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Synthesis of heterocyclic enol ethers and their use as a group 2 metabotropic glutamate receptor antagonists.
Kolczewski et al.
Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
Brauner-Osbourne et al.
Curr.Drug Targets., 2007;8:169